Lopid Patent Term Restoration and Fairness Act of 1987: Hearing Before the Subcommittee on Courts, Civil Liberties, and the Administration of Justice of the Committee on the Judiciary, House of Representatives, One Hundredth Congress, First Session, October 8, 1987, Volume 4U.S. Government Printing Office, 1988 - 350 pages |
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Page 95
... ratio increased from 34 · 5 ± 1 · 1 ( mean ± SEM ) to 37 · 5 ± 1 · 6 ( p < 0 · 05 ) on cessation of treatment . Similarly , the serum apo A - II / HDL - cholesterol ratio increased from 106 ± 3 to 118 ± 3 ( p < 0 · 001 ) . There was a ...
... ratio increased from 34 · 5 ± 1 · 1 ( mean ± SEM ) to 37 · 5 ± 1 · 6 ( p < 0 · 05 ) on cessation of treatment . Similarly , the serum apo A - II / HDL - cholesterol ratio increased from 106 ± 3 to 118 ± 3 ( p < 0 · 001 ) . There was a ...
Page 104
... ratio and triglycerides were Table 1 Patient details * Age ( mean and range years ) Males / females Peripheral vascular disease Myocardial infarction Angina Treated Controls 63.6 ( 55-72 ) 9/1 7 5 6 65.6 ( 53-75 ) 4/0 1 4 1 * Most ...
... ratio and triglycerides were Table 1 Patient details * Age ( mean and range years ) Males / females Peripheral vascular disease Myocardial infarction Angina Treated Controls 63.6 ( 55-72 ) 9/1 7 5 6 65.6 ( 53-75 ) 4/0 1 4 1 * Most ...
Page 111
... ratio was about 32 per cent , from 7.15 to 4.90 . Table 3 shows that gemfibrozil treatment reduced total triglyceride levels , as well as those of the various lipoprotein fractions . In contrast to its effects on cholesterol , 1.2 g of ...
... ratio was about 32 per cent , from 7.15 to 4.90 . Table 3 shows that gemfibrozil treatment reduced total triglyceride levels , as well as those of the various lipoprotein fractions . In contrast to its effects on cholesterol , 1.2 g of ...
Page 114
... ratio of HDL / total cholesterol increased significantly . There was also a significant increase in apolipoprotein A - I and A - II concentrations but the ratio of apoprotein A - I / A - II remained unchanged . Cholesterol transfer by ...
... ratio of HDL / total cholesterol increased significantly . There was also a significant increase in apolipoprotein A - I and A - II concentrations but the ratio of apoprotein A - I / A - II remained unchanged . Cholesterol transfer by ...
Page 115
... ratio of HDL - cholesterol / total cholesterol also showed a significant increase ( p < 0 · 001 ) . The effect of gemfibrozil was noted within 1 month of the beginning of treatment . Thereafter it was sustained during management ...
... ratio of HDL - cholesterol / total cholesterol also showed a significant increase ( p < 0 · 001 ) . The effect of gemfibrozil was noted within 1 month of the beginning of treatment . Thereafter it was sustained during management ...
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apolipoprotein Association atherosclerosis baseline bill blood Capsules cardiovascular cent Chairman changes cholesterol cholesterol levels cholestyramine clofibrate Committee concentrations coronary heart disease decrease diabetic diet dose Drug Administration dyslipidaemic effect of gemfibrozil elevated fatty acid composition FDA approval Finland follow-up Food and Drug Framingham gemfibrozil treatment glucose HDL-cholesterol Health heart attacks Helsinki Heart Study hypercholesterolaemia hypertension incidence increase ischaemic heart disease Journal KASTENMEIER Kaukola laboratory legislation lipid lowering Lipid Research Clinics lipid-lowering lipoprotein cholesterol lipoprotein lipase lipoprotein lipase activity Lithell long-term Lopid Lopid patent low density lipoprotein LRC-CPPT male Manninen market exclusivity metabolism mmol/l mortality myocardial infarction Parke-Davis patent extension patent term extension patients pharmaceutical Phase IV study placebo Primary Prevention Trial ratio reduction regulatory risk factors Royal Society safety serum cholesterol serum lipid significant Society of Medicine Subcommittee Table Term Restoration Act therapy treatment groups triglycerides Vessby VLDL Warner-Lambert Waxman-Hatch
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