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Royal Society of Medicine Services Limited
International Congress and Symposium Series

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ROYAL SOCIETY OF MEDICINE SERVICES LIMITED 1 Wimpole Street, London WIM 8AE

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All rights reserved. No part of this book may be reproduced in any form by photostat, microfilm. or any other means, without written permission from the publishers.

This publication is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Apart from any fair dealing under the UK Copyright Act 1956, Part 1, Section 7, no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the Honorary Editors, Royal Society of Medicine.

These proceedings are published by Royal Society of Medicine Services Ltd with financial support from the sponsor. The contributors are responsible for the scientific content and for the views expressed, which are not necessarily those of the sponsor, of the editor of the series or of the volume, of the Royal Society of Medicine or of Royal Society of Medicine Services Ltd. Distribution has been in accordance with the wishes of the sponsor but a copy is available to any Fellow of the Society at a privileged price.

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Phototypeset by Dobbie Typesetting Service, Plymouth, Devon

Printed in Great Britain at the University Press, Oxford

Contributors

D. Canter MA, MB, ChB, FRCS

International Clinical Research, Warner-Lambert/Parke-Davis, Pontypool,
Gwent NP4 OYA, UK

B. Ek MD

Department of Medicine, University of Umeå, S-901 85. Umea,
Sweden

Helsinki Heart Study Ethical Committee

Albertinkatu 23A, PL228, 00121 Helsinki 12, Finland

S. Kaukola MD

H. Meinertz MD

First Department of Medicine, Helsinki University Central Hospital,
SF-00290, Helsinki 29, Finland

Department of Medicine B, Rigshospital DK-2100, Copenhagen Ø,
Denmark

J. R. O'Brien DM, FRCP, FRCPath

B. Vessby MD

Portsmouth District Pathology Service Central Laboratory, St Mary's
Hospital, Portsmouth, PO3 6AG, UK

Department of Geriatrics, University of Uppsala, PO Box 12042, S-750,
Uppsala, Sweden

Contents

List of contributors

Influence of gemfibrozil on lipoprotein composition: triglyceride removal capacity and fatty acid composition of the plasma lipid esters

BENGT VESSBY, MERIKE BOBERG and HANS LITHELL .

Effect of gemfibrozil on some haematological parameters

J. R. O'BRIEN, M. D. ETHERINGTON, R. D. SHUTTLEWORTH, CHERYL M.
ADAMS, J. E. MIDDLETON and F. C. GOODLAND .

Effects of gemfibrozil on plasma lipoproteins in patients with
Type II hyperlipoproteinaemia and familial hypercholesterolaemia
HANS MEINERTZ.

Gemfibrozil increases HDL-cholesterol and apolipoprotein A-I and A-Il concentrations in dyslipidaemic subjects

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11

15

SIRKKA KAUKOLA, VESA MANNINEN, CHRISTIAN EHNHOLM and
MARJATTA MÄLKÖNEN.

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Augmentation of gemfibrozil-induced hypolipidaemia by psylliumbased fibre

BÖRJE EK, MARJATTA MÄLKÖNEN and VESA MANNINEN

Long-term treatment with gemfibrozil in male survivors of myocardial infarction

SIRKKA KAUKOLA, MARJATTA MÄLKÖNEN, PEKKA KOSKINEN and VESA
MANNINEN.

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35

VIII

Contents

Long-term studies with gemfibrozil in Finland: an 8-year follow-up

DAVID CANTER

Safety as a factor in lipid-regulating primary prevention drug trials: the Helsinki Heart Study Interim Report

HELSINKI HEART STUDY ETHICAL COMMITTEE

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51

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