High-Throughput Synthesis: Principles and PracticesIrving Sucholeiki CRC Press, 2001 M02 22 - 400 pages An exploration of high-throughput synthesis, this book presents a compilation of how-to methods, novel materials, and catalyst developments for creating a multitude of new compounds. Introductory sections are coupled with in-depth case studies clarifying theory through practice. The book emphasizes the potential for reproducing experiments in detail. |
Other editions - View all
Common terms and phrases
acetate activity added aldehydes Aldrich amide amine loading amino acid Anal analysis approach array assay automated beads catalyst Chem chemical chloride cleavage cleaved combinatorial chemistry composition compounds containing coupling cross-linked deprotection DIEA dielectric encoded ester Figure filtered filtration fluorescent fluorous Fmoc formation functional high-throughput screening HPLC HPLC purity retention large numbers ligand linker liquid liquid-liquid extraction mass recovery yield materials chips membrane MeOH Merrifield methanol methods methyl microfluidic microtiter plate microwave mmol mmol/g molecular molecules ninhydrin optical organic synthesis oxide peptide synthesis piperidine polymer polypropylene polystyrene precursors prepared procedure R₁ reaction mixture reaction vessels reactor reagents removed resin resin-bound resulting robot sample scaffold Scheme sensors shaker solid phase organic solid support solid-phase synthesis solution solvent step studies substrate Sucholeiki syringe tags techniques temperature Tetrahedron Lett tion trifluoroacetic acid tubes vials washed with DMF