Alcohol and the Gastrointestinal Tract

Front Cover
Manfred V. Singer, David Brenner
Karger Medical and Scientific Publishers, 2006 - 262 pages
Alcohol-related disorders account for an enormous part of the global mortality and morbidity, with most patients being treated in gastroenterology. For this book, a team of internationally renowned experts has contributed state-of-the-art reviews on alcohol-related epidemiology, diseases of the gastrointestinal tract, liver and pancreas as well as the question of how to guide alcoholics psychologically. The first paper evaluates epidemiological data on the impact of alcohol consumption on total morbidity and mortality. This is followed by a critical appraisal of the effect of moderate drinking on the risk and pathophysiological mechanisms of gastrointestinal diseases and of certain health benefits of moderate alcohol consumption. An assessment of available animal models to explain the latest findings in basic alcohol research is followed by a discussion of the effects of alcohol on the various parts of the gastrointestinal system, with special emphasis on the pancreas and liver. Reviews of the well-known association between alcohol consumption and increased risk of cancer and a discussion on how best to care for alcoholics in view of the presented research advances conclude this volume. For those interested in alcohol-related epidemiology, molecular mechanisms, pathophysiology, clinical aspects and the treatment of alcohol-induced diseases of the gastrointestinal tract, liver and pancreas, this publication contains a wealth of information.

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Contents

Current Needs and Methodological Challenges
1
Moderate Alcohol Consumption and the Gastrointestinal Tract
15
A Review of Pathophysiological Processes
27
Animal Models and Their Results in Gastrointestinal Alcohol Research
35
AlcoholRelated Diseases of the Mouth and Throat
59
AlcoholRelated Diseases of the Esophagus and Stomach
74
Effect of Alcohol Consumption on the Gut
91
Alcoholic Pancreatitis
105
Genetic Polymorphisms in Alcoholic Pancreatitis
148
Clinical Syndromes of Alcoholic Liver Disease
161
Molecular Mechanisms of AlcoholInduced Hepatic Fibrosis
177
Treatment of Alcoholic Liver Disease
196
Alcohol and Hepatitis C
214
Alcohol Consumption and Cancer of the Gastrointestinal Tract
234
Guidelines for Practitioners
246
Author Index
256

Molecular Mechanisms of Alcoholic Pancreatitis
122
Treatment of Alcoholic Pancreatitis
139

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