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Schmidt, Robinette Foundation and University of Pennsylvania School of Medicine, beginning July 1, 1952. HACKEL, DONALD BENJAMIN, Cleveland, Ohio, 31; Harvard Medical School, 1946;

cardiac metabolism in intact dogs studied by venous catheterization of the coronary sinus; under Thomas D. Kinney, City Hospital and Western Reserve

University School of Medicine, beginning July 1, 1952. HADDY, FRANCIS JOHN, St. Paul, Minn., 30; University of Minnesota Medical

School, 1947; pulmonary vascular resistance; pulmonary edema; under Maurice B. Visscher, University of Minnesota Medical School, beginning October

1, 1952. KHAIRALLAH, PHILIP A., Durham, N. C., 24; Columbia University College of

Physicians and Surgeons, 1951 ; biochemistry of heart muscle, proteins; under W. F. H. M. Mommaerts, Duke University School of Medicine, beginning

September 1, 1952. LANDON, ERWIN JACOB, Berkeley, Calif., 27; University of Chicago School of

Medicine, 1948; studies on the metabolism of steroid compounds-possible relationships to cardiovascular disease; under David M. Greenberg, University

of California School of Medicine, beginning July 1, 1952. MILLER, JOSEPH HENRY, Los Angeles, Calif., 29; University of Colorado School

of Medicine, 1947; development and application of a mechanical heart-lung for intracardiac surgery in the human; under Harry Goldblatt, Cedars of

Lebanon Hospital (Los Angeles), beginning January 1, 1953. NELSON, CLIFFORD VINCENT, London, England, 37; B. S. (in electrical engineer

ing), Massachusetts Institute of Technology, 1942; the electrical field of the heart; under E. C. Cherry and W. F. Floyd, Imperial College of Science, Middle

sex Hospital Medical School (London), beginning April 1, 1952. OSBORN, JOHN JAY, Woodbury, N. Y., 35; Johns Hopkins University School of

Medicine, 1943; continuation of work on experimental studies of methods for the interruption of the cardiac and pulmonary circulations, by whole-body refrigeration and mechanical oxygenation; under L. Emmett Holt, Jr., New York University-Bellevue Medical Center, beginning July 1, 1952.

NEW RESEARCH FELLOWS

BIGGs, Max WILLIAM, Oakland, Calif., 32; Harvard Medical School, 1945 ; lipopro

tein metabolism in health and disease; under John H. Lawrence, Donner Labo

ratory, University of California School of Medicine, beginning July 1, 1952. GARB, SOLOMON, New York, N. Y., 32; Cornell University Medical College, 1943;

physiology and pharmacology of isolated mammalian heart muscle; under

McKeen Cattell, Cornell University Medical College, beginning July 1, 1952. KIBLER, ROBERT FRANKLIN, Durham, N. C., 28; Duke University School of Medi

cine, 1948; splanchnic circulation and metabolism; under J. D. Myers, Duke

University School of Medicine, beginning July 1, 1952. KLEINERMAN, JEROME I., Cleveland, Ohio, 29; University of Pittsburgh School of

Medicine, 1946; studies of myocardial nutrition and circulation in animals by the radiosodium clearance method; under Thomas D. Kinney, Cleveland City Hospital, beginning July 1, 1952. MCINTOSH, HENRY DEANE, Durham, N. C., 31; University of Pennsylvania School

of Medicine, 1950; receptor areas in the control of blood volume and electrolytes in man; under James V. Warren, Duke University School of Medicine, begin

ning July 1, 1952. MALLOV, SAMUEL, Syracuse, N. Y., 33; Ph. D., University of Syracuse Medical

College (in biochemistry), to be conferred in 1952; effects of ethyl alcohol and acetaldehyde on the metabolism of the myocardium and other tissues; under

Jay Tepperman, Syracuse University Medical College, beginning July 1, 1952. MATEER, FRANK MARION, Pittsburgh, Pa., 31 ; University of Pittsburgh School of

Medicine, 1944; cardiovascular effects of specific electrolyte depletion and repletion studied by means of dialysis technique and ballistocardiographic studies in the normal and abnormal subject; under T. S. Danowski, University of Pittsburgh School of Medicine, beginning July 1, 1952. MAXWELL, MORTON HARRISON, Los Angeles, Calif., 28; Columbia University

College of Physicians and Surgeons, 1946; mechanism of heart failure; under Myron Prinzmetal, Cedars of Lebanon Hospital (Los Angeles), beginning Sep

tember 1, 1952. METCALF, JAMES, Needham, Mass., 30; Harvard Medical School, 1946; changes

during pregnancy in the circulation and respiration of normal women and those with heart and pulmonary disease; under C. Sidney Burwell, Boston Lying-In Hospital, beginning July 1, 1952.

MITCHELL, GEORGE LEE, JR., Decatur, Ga., 34; Emory University School of Medic'

cine, 1950; serum and muscle electrolyte studies in various disease states; under

A. J. Merrill, Emory University School of Medicine, beginning July 1, 1952. ROWE, GEORGE GILES, Madison, Wis., 31; University of Wisconsin Medical School,

1945; a clinical study of the role of the sympathetic nervous system in hypertension evaluated via the action of sympatholytic and depressor drugs; under Charles W. Crumpton, University of Wisconsin Medical School, beginning July 1, 1952.

The stipend for established investigators is at the rate of $6,000 to $9,000 per annum and for research fellows, $3,500 to $5,500 per annum.

RESEARCH GRANTS-IN-AID

CONTINUED GRANT AWARDS

Amount, 1952-53 Western Reserve University School of Medicine, Cleveland, to study

in vivo the microscopic changes in the circulating blood and the reactions of small blood vessels in patients with heart disease and thromboembolism receiving anticoagulant therapy, by Edward H. Bloch. July 1, 1951-June 30, 1953_.

$3, 864.00 Mary Imogene Bassett Hospital, Cooperstown, N. Y., for a correlation

of the morphologic and metabolic aspects of cell damage, by Joseph W. Ferrebee. Sept. 15, 1951-Sept. 14, 1954_

7, 140.00 University of Minnesota Medical School, Minneapolis, for the investi

gation of etiologic and pathogenic mechanisms in rheumatic fever as revealed through studies of basic relationships of immunological, endocrinological, and biochemical events to pathologic processes related to those responsible for rheumatic disease, by Robert A. Good. July 1, 1951-June 30, 1954_

6, 825.00 University of Pennsylvania School of Medicine, Philadelphia, for the

study of the biochemical pathways by which cholesterol and fat are synthesized and matabolized in the body; the action of hormones upon the biosynthesis of cholesterol and lipids, by Samuel Gurin. Sept. 1, 1951-Aug. 31, 1954.

10,500.00 Oklahoma Medical Research Institute, Oklahoma City, for the study of

the influence of adrenal cortical hormones on cardiac lesions and

enzymes, by Charles D. Kochakian. July 1, 1951-June 30, 1953_--- 4,200.00 Tulane University of Louisiana School of Medicine, New Orleans, for

the study of cytochemical and histochemical approaches to renal

physiology, with particular reference to electrolyte reabsorption in i congestive failure, by Nathaniel B. Kurnick. July 1, 1950–June 30, 1953_

9, 135. 00 Massachusetts General Hospital, Boston, for the study of factors

that regulate extracellular fluid volume in the normal and edemat

ous subject, by Alexander Leaf. July 1, 1951-June 30, 1953_-. 4, 725.00 Tulane University of Louisiana School of Medicine, New Orleans,

for the study of hemodynamic and iron-storing function of ferritin, with particular reference to the kidney, by H. S. Mayerson. July 1, 1950–June 30, 1953_

3, 675.00 University of Michigan Medical School, Ann Arbor, for the study of

cardiac metabolism as related to epinephrine-induced arrhythmias

and tachycardia, by Mark Nickerson. Sept. 1, 1951-Aug. 31, 1953_- 5,880.00 Cornell University Medical College, New York, for the study of the

relationship between increased activity of the adrenal cortex and posterior lobe of the pituitary gland and fluid and electrolyte reí tention in edema, by Robert F. Pitts. July 1, 1950_June 30, 1953_- 8,085.00 Council on Rheumatic Fever and Congenital Heart Disease, for cooperative research study of the relative effectiveness of ACTH and Cortisone in the treatment of rheumatic fever and the prevention of rheumatic heart disease. David D. Rutstein, Chairman. Jan. 1, 1951-Dec. 31, 1955_

3,500.00 Yale University School of Medicine, New Haven, for the study of the

metabolic basis for heart failure and for treatment of the same, by William T. Salter. July 1, 1951-June 30, 1953_

3, 885. 00

CONTINUED GRANT AWARDS-continued
State University of New York Medical Center at Syracuse, N. Y., for

the study of the nervous control of water and electrolyte exertion
by the normal kidney, by Otto W. Sartorius. July 1, 1951-June 30,
1953_

$4, 515.00 Marine Biological Laboratory, Woods Hole, Mass., for the study of

molecular mechanism of muscular contraction, by Albert SzentGyorgyi. July 15, 1951-July 14, 1954.--

10,000.00 Harvard Medical School, Boston, for studies on the relationship of

the adrenal to hypertension, by George W. Thorn. July 1, 1951-June 30, 1954.

4, 200.00 Duke University School of Medicine, Durham, for the study of the re

sponse of the pulmonary vascular bed to hemodynamic alterations in the systematic circulation, by James V. Warren. July 1, 1950 June 30, 1953

5, 250.00 New England Center Hospital, Boston, for the physiologic investiga

tion of experimental isolated pulmonary insufficiency and pure rightsided heart failure, by C. Stuart Welch. July 1, 1951-June 30, 1953. 5, 250.00

NEW GRANT AWARDS

Medical College of Georgia, Augusta, for the study of the comparative

effects of the adrenolytic agents on the cardiovascular system of the dog when administered in the presence of humoral or neurogenic

hypertension, by Raymond P. Alquist. July 1, 1952-June 30, 1954_-- 4, 462. 50 Bowman Gray School of Medicine, Winston-Salem, for the study of

immunophysiology, by Jerry K. Aikawa. Oct. 1, 1952-Sept. 30, 1953_

3, 150.00 Hahnemann Medical College and Hospital, Philadelphia, for the study

of investigation of the cardiovascular and respiratory dynamics in patients with valvular deformities before and after surgery, by Charles P. Bailey. July 1, 1952-June 30, 1954_

5, 250.00 La Rabida Jackson Park Sanitarium, Chicago, for the study of the nature and mode of action of the substance in testicular extract causing increased vascular permeability, by Earl P. Benditt. July 1, 1952-June 30, 1953_--

5, 302. 50 Temple University School of Medicine, Philadelphia, for the study of

the nature of endocarditis and glomerulonephritis in animals with arteriovenous fistulae, as well as obtaining more information on factors influencing susceptibility to these diseases, by J. Richard Bobb. July 1, 1952-June 30, 1953_

2, 625.00 Mary Imogene Bassett Hospital, Cooperstown, N. Y., for the study of

lung volume restriction as a respiratory stimulus in normal subjects and patients with cardiorespiratory disease, by James Bordley III. Apr. 1, 1952-Mar. 31, 1953_-

5, 250.00 Columbia University College of Physicians and Surgeons, New York,

for the study of renal and hepatic vascular reactivity in glomerulonephritis, essential hypertension and cirrhosis, by Stanley E. Bradley. July 1, 1952–June 30, 1953. Sponsored by the Westchester Heart Association

3, 675.00 The Johns Hopkins Hospital School of Medicine, Baltimore, for the

study of autonomic effects of cerebral cortex on experimental renal

hypertension, by Kenneth M. Browne. July 1, 1952-June 30, 1953_. 3, 675. 00 Massachusetts Institute of Technology, Boston, for the study of chem

ical investigation of the heart, active principle of Crataegus (Hawthorne), by George H. Buchi. July 1, 1952-June 30, 1953.,

6,300.00 Cornell University Medical College, New York, for the study of effects

of drugs and poisons on the action potentials and automaticity of

heart muscle, by McKeen Cattell. July 1, 1952-June 30, 1953__ 4, 971. 35 Fels Research Institute, Antioch College, Yellow Springs, Ohio, for

the application of the Fels oxygenator in prolonged bypass of heart and lungs, by Leland C. Clark. July 1, 1952-June 30, 1953_

3,675.00 University of Pennsylvania, Graduate School of Medicine, Phila

delphia, for the measurement of the work of breathing and pulmonary function in patients with dyspnea, by Julius H. Comroe. July 1, 1952–June 30, 1954_.

6,300.00

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University of Pittsburgh School of Medicine, Pittsburgh, for studies of

cardiovascular effects of cation and anion depletion by vivodialysis by F. S. Danowski. July 1, 1952—June 30, 1953_

$6, 195.00 Columbia University College of Physicians and Surgeons, New York,

for studies of fresh and preserved vascular grafts during various types of preservation; the effect of certain drugs on the implanted grafts and anastomoses, by Ralph A. Deterling, Jr. July 1, 1952June 30, 1953_

7, 350.00 Wayne University, Detroit, for the isolation, chemical proof of struc

ture, and pharmacological examination of the heart poison from Pilocereus Sargentianus Orcutt, by Carl Djerassi. July 1, 1952– June 30, 1953_-

6, 184. 50 Faculty of Medicine, McGill University, Montreal, for studies tracing

fate of labeled cellular elements in atherosclerotic lesions in rabbits fed cholesterol, by G. Lyman Duff. July 1, 1952-June 30, 1953. Renewal..

5, 013. 75 University of California School of Medicine, San Francisco, for

studies on water distribution and water kinetics in patients with

edema, by Isidore S. Edelman. July 1, 1952-June 30, 1953----- 3, 675.00 University of Pennsylvania School of Medicine, Philadelphia, for

studies on the supra-optico-hypophyseal system in the normal dog pertaining to volume regulation; an effort to provide at least a partial explanation of certain phenomena observed in markedly edematous patients with heart disease, by J. Russell Elkinton and Russell D. Squires. July 1, 1952-June 30, 1953_,

4,200.00 State University of New York, Syracuse, N. Y., for the study of

some substrates and enzyme inhibitors on cardiac muscle by Alfred Farah. Apr. 1, 1952–Mar. 31, 1953_

4, 410.00 Am can University of Beirut, Beirut, Lebanon, for the effect of

Krebs cycle inhibitors on the performance and metabolism of the isolated mammalian heart and the effect of cortical hormones on the salt and water excertion in a heart-lung-kidney preparation, by George Fawaz. July 1, 1952-June 30, 1954..

4, 725. 00 Emory University School of Medicine, Atlanta, for the study of the

nature of the vascular response to sodium restriction, by Eugene B. Ferris and Albert A. Brust. July 1, 1952-June 30, 1955_

5, 250.00 University of Maryland Medical School, Baltimore, for the study of

factors causing obesity and the influence of obesity in the development of arteriosclerosis and other cardiovascular diseases, by Frank H. J. Figge. July 1, 1952-June 30, 1953_-

5, 166.00 Mount Sinai Hospital, New York, for the study of the volume of the

respiratory dead space and the composition of alveolar gas in subjects with cardiopulmonary disease, and the continuation of studies on congestive heart failure in dogs, by Alfred P. Fishman. Sept. 1, 1952-Aug. 31, 1953_.

3, 675.00 Georgetown University School of Medicine, Washington, D. C., for

hemodynamic studies in dogs using a variable heart pump permitting independent control of rate, output, and ejection velocity, by Edward D. Freis. July 1, 1952-June 30, 1954_

5, 250.00 Mount Zion Hospital, San Francisco, for studies concerning the metab

olism of cholesterol, by Meyer Friedman. July 1, 1952-June 30, 1953

6,300.00 Washington University School of Medicine, St. Louis, for the study of

metabolic factors in experimental heart failure, by Robert F. Furchgott. July 1, 1952-June 30, 1954_

5, 250.00 Johns Hopkins Medical School, Baltimore, Md., for the analysis of the

role of the personal factor and of certain drugs in experimental

tachycardia, by W. Horsley Gantt. July 1, 1952–June 30, 1953_-- 5, 250.00 Institute for Medical Research, Los Angeles, for the study of capillary

circulation in experimental renal hypertension in dogs, by Harry Goldblatt. Jan. 1, 1953–Dec. 31, 1952_

3, 780.00 Vanderbilt University School of Medicine, Nashville, for the applica

tion of the oxygenator to acute heart failure, by Frank Gollan. July 1, 1952-June 30, 1953_.

3, 675.00 39087-53-pt. 1

6

NEW GRANT AWARDS—continued

Yale University School of Medicine, New Haven, for the study of

hemodynamic factors affecting electrolyte metabolism and the renal excretion of electrolytes, by Allen V. N. Goodyer. July 1, 1952-June 30, 1953

$5, 775.00 Bowman Gray School of Medicine, Winston-Salem, to study the nature

of and the factors leading to the production of the vasoconstriction and the vasodilation which develops in perfused organs, by Harold D. Green, July 1, 1952-June 30, 1954---

4, 830.00 University of California, Berkeley, for tracer studies of the inter

mediate metabolism of amino acids and related compounds of significance for hypertension and arteriosclerosis, by David M. Greenberg. July 1, 1952-June 30, 1953_

5, 250.00 University of California, Berkeley, in aid of the investigation of

steroid metabolism and possible relations to cardiovascular disease, by David M. Greenberg. July 1, 1952-June 30, 1953_

525.00 University of Texas Medical Branch, Galveston, for the study of endo

crine and other factors in the induction and pathogenesis of experimental hypertension with special reference to parabiotic hypertension, by Charles E. Hall. July 1, 1952-June 30, 1953_.

5, 985.00 University of Utah, School of Medicine, Salt Lake City, for the study

of pharmacology, physiology, and biochemistry of the heart, by Stewart C. Harvey July 1, 1952-June 30, 1953. Renewal.

6,300.00 Presbyterian Hospital, Chicago, for the study of identification of the

conduction system of the heart, by George M. Hass. July 1, 1952June 30, 1953

4, 200.00 University of Tennessee School of Medicine, Memphis, for the study of

the role of the heart, blood vessels, liver and altered body fluids in the hypertension arising in dogs living a month or longer without kidneys, by C. Riley Houck. July 1, 1952-June 30, 1953..

5, 250.00 Columbia University, College of Physicians and Surgeons, New York,

for the study of cardiovascular problems related to surgery, by George H. Humphreys II. Apr. 1, 1952-Mar. 31, 1953_

4,200.00 University of Utah School of Medicine, Salt Lake City, for the study of

adrenal hormones in the blood of patients with rheumatic fever and

related conditions, by Vincent C. Kelley. July 1, 1952-June 30, 1954. 5, 250.00 Cleveland City Hospital, Cleveland, for the study of effective myocar

dial circulation or nutrition as studied by the myocardial clearance of radiosodium, by Thomas D. Kinney and Jerome Kleinerman. July 1, 1952-June 30, 1953_

3, 150.00 University of Tennessee School of Medicine, Memphis, for the study of

the role of ventricular filling in the production of the heart sounds with special attention to the etiology of the first and third sound, by Robert C. Little. July 1, 1952-June 30, 1954.

2, 992.50 Washington University Medical School, St. Louis, for the study of the

isolation of specific heart proteins which bind cardiac drugs, by Oliver H. Lowry. July 1, 1952-June 30, 1954_

2, 940.00 State University of New York School of Medicine, Syracuse, for the

study of the effects of ethyl alcohol and acetalydehyde on the metabolism of the myocardium and other tissues, by Samuel Mallov, Sept. 1, 1952-Aug. 31, 1953_

525.00 Peter Bent Brigham Hospital, Boston, for an investigation into the

relation of renal failure to certain disorders of the cardiovascular system, by John P. Merrill. July 1, 1952-June 30, 1953_,

5, 250.00 Dartmouth Medical School, Hanover, N. H., for the further develop

ment and application of electrical impedance methods to the measurement of various cardiac and circulatory problems, by Jan Nyboer. July 1, 1952-June 30, 1953__

3, 150.00 University of Pittsburgh School of Public Health, Pittsburgh, for the

study of congestive heart failure due to valvular disease upon myocardial metabolism in dogs, by Robert E. Olson. July 1, 1952June 30, 1955_-

8, 925.00 New York University-Bellevue Medical Center, New York, for experi

mental studies on methods for the interruption of the cardiac and pulmonary circulations by refrigeration and with a new type of oxygenator, by John J. Osborn. July 1, 1952-June 30, 1953

5, 670.00

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