Handbook of Developmental ToxicologyCRC Press, 1996 M10 23 - 784 pages Developmental toxicology, an increasingly important area, encompasses the study of toxicant effects on development, from conception through puberty. The Handbook of Developmental Toxicology provides useful insights gained from hands-on experience, as well as a theoretical foundation. In this convenient reference you will find information not previously gathered in one source-including comparative developmental milestones, historical data, and a glossary of terms used in developmental toxicity evaluation. This handbook is a practical guide for individuals who are responsible for testing chemical agents and for regulatory scientists who must evaluate studies, interpret data, and perform risk assessments. Packed with features, the Handbook of Developmental Toxicology is ideal for training students and technicians in developmental toxicology. |
Contents
Experimental Approaches | 15 |
Experimental Approaches to Evaluate Mechanisms of Developmental Toxicity | 17 |
Nucleic Acids | 24 |
Chapter 3 | 32 |
Pathogenesis of Abnormal Development | 45 |
Pathogenesis of Abnormal | 49 |
Kathleen K Sulik | 59 |
Maternally Maternally Mediated Effects | 62 |
Use of Toxicokinetics in Developmental Toxicology | 423 |
Molecular Techniques in Developmental Toxicology | 443 |
The research described in this chapter has been reviewed by the National Health and Environment Effects Research | 459 |
In Vitro Methods for the Study of Mechanisms of Developmental Toxicity | 465 |
Methods for Analyses and Features of Pathogenesis Associated with | 506 |
Experimental Design and Statistical Analysis for Developmental Toxicologist | 511 |
WHAT IS PATHOGENESIS? | 518 |
Quality Concerns for Developmental Toxicologists | 529 |
Chapter 4 | 79 |
Conclusions | 91 |
Chapter 6 | 111 |
Developmental Toxicity TestingMethodology | 175 |
Chapter 8 | 227 |
Developmental Neurotoxicity Testing Methodology | 291 |
Developmental Neurotoxicity TestingData Evaluation | 325 |
Methods and Data Evaluation | 357 |
Role of Xenobiotic Metabolism in Developmental Toxicity | 383 |
Perspectives on the U S EEC and Japanese Developmental Toxicity | 551 |
Human StudiesEpidemiologic Techniques in Developmental Toxicology | 597 |
MODELING AND RISK ASSESSMENT | 633 |
Chapter 21 | 667 |
A Glossary of Fetal Anomalies | 697 |
B Historical Control Data | 713 |
Bibliography of Reproductive and Developmental Toxicology Test | 735 |
Common terms and phrases
abnormal activity agents alterations analysis animals assessment behavioral Biochem Biol blastocyst body weight cell death chemical cleft palate cyclophosphamide cytochrome P-450 detection developmental toxicity studies developmental toxicology differentiation distribution dosage dose group dose-response drugs embryo embryogenesis enzyme evaluation examined example experimental exposure factors females fetal fetus fetuses function gene germ cells gestation gestation day glucocorticoids growth guidelines human implantation increased induced inhibition investigators laboratory levels limb litter liver male malformations maternal toxicity mating mechanisms metabolism method mice morphogenesis mouse embryos mRNA Mutagen mutations neural folds neural tube normal observed offspring organ organogenesis outcome palate Pharmacol placenta postnatal potential pregnancy preimplantation prenatal protein pups rabbits rat embryos receptor reproductive response result retinoic acid ribs risk rodents sample skeletal specific sperm statistical sternebrae stress TABLE teratogenesis teratogenic Teratology tissue Toxicol toxicology treatment uterine vitro xenobiotic yolk sac