Medical Uses of StatisticsJohn C. Bailar III, Frederick Mosteller CRC Press, 2019 M05 20 - 480 pages This work explains the purpose of statistical methods in medical studies and analyzes the statistical techniques used by clinical investigators, with special emphasis on studies published in "The New England Journal of Medicine". It clarifies fundamental concepts of statistical design and analysis, and facilitates the understanding of research results. |
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Page 6
... observations and makes use of such statistical concepts as bias and variability. Its premise is that when the laws of probability are known to have governed the acquisition of data, then statistical inferences have the force of logical ...
... observations and makes use of such statistical concepts as bias and variability. Its premise is that when the laws of probability are known to have governed the acquisition of data, then statistical inferences have the force of logical ...
Page 9
... observe different groups or similar groups in different epochs, the problems are likely to be markedly more difficult to solve. For example, the record may not always contain sufficient information for the operational definition of ...
... observe different groups or similar groups in different epochs, the problems are likely to be markedly more difficult to solve. For example, the record may not always contain sufficient information for the operational definition of ...
Page 12
... observed between high- and low-compliance subjects whose medication was the placebo. Drug compliance, a matter of personal choice, was for some reason related to mortality in the patients in this study. Had there not been a placebo ...
... observed between high- and low-compliance subjects whose medication was the placebo. Drug compliance, a matter of personal choice, was for some reason related to mortality in the patients in this study. Had there not been a placebo ...
Page 13
... observed in these periods could be thought of as random outcomes of complex probabilistic processes; we happen to have relatively brief peeks at these processes; each death rate we have observed indicates the average level of risk per ...
... observed in these periods could be thought of as random outcomes of complex probabilistic processes; we happen to have relatively brief peeks at these processes; each death rate we have observed indicates the average level of risk per ...
Page 14
... observations we would learn, in the problem with the die, the probabilities that it would come to rest showing 1,2,3 ... observations in a sample. The sample mean (the familiar average, learned in grade school) is a statistic that tells ...
... observations we would learn, in the problem with the die, the probabilities that it would come to rest showing 1,2,3 ... observations in a sample. The sample mean (the familiar average, learned in grade school) is a statistic that tells ...
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analysis applied assessment assigned authors average calculated called cancer Chapter clinical trials combined comparison considered crossover decision depends described determine discussed disease drug effects Engl England Journal error estimate example expected experiment Figure findings fitted four give given groups Health hospital hypothesis important improvement included increase indicated interpretation interval issues Journal less means measurements ment meta-analysis mortality multiple myocardial infarction N Engl observed original outcome patients percent period population possible present probability problems procedures published questions randomized readers reasons reduce REFERENCES regression relation reported requires response risk sample scientific selection shows significant sometimes specific standard statistical methods subjects Table techniques therapy tion treated treatment usually variables variance Yes Yes