Medical Uses of StatisticsJohn C. Bailar III, Frederick Mosteller CRC Press, 2019 M05 20 - 480 pages This work explains the purpose of statistical methods in medical studies and analyzes the statistical techniques used by clinical investigators, with special emphasis on studies published in "The New England Journal of Medicine". It clarifies fundamental concepts of statistical design and analysis, and facilitates the understanding of research results. |
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Page viii
... Experiments— Parallel Comparisons of Treatment Philip W. Lavoriy Thomas A. Louis, John C. BailarIIIy and Marcia Polansky 61 Chapter 5 Crossover and Self-Controlled Designs in Clinical Research Thomas A. Louisy Philip W. Lavoriy John C ...
... Experiments— Parallel Comparisons of Treatment Philip W. Lavoriy Thomas A. Louis, John C. BailarIIIy and Marcia Polansky 61 Chapter 5 Crossover and Self-Controlled Designs in Clinical Research Thomas A. Louisy Philip W. Lavoriy John C ...
Page xxiii
... experiments to future human experience. The next chapter (Statistical Analysis in the Journal) tells how often various statistical procedures were used in the Journal during a two-year period. A brief follow-up notes new emphasis on ...
... experiments to future human experience. The next chapter (Statistical Analysis in the Journal) tells how often various statistical procedures were used in the Journal during a two-year period. A brief follow-up notes new emphasis on ...
Page 11
... experiment is carried out, treatments are imposed and subsequent events are followed; these procedures make causal inference much more direct, but dependence on outside knowledge is unlikely to be wholly absent. The point would be ...
... experiment is carried out, treatments are imposed and subsequent events are followed; these procedures make causal inference much more direct, but dependence on outside knowledge is unlikely to be wholly absent. The point would be ...
Page 19
... experiment, definitively demonstrated protection by the vaccine, which cut the polio rate by a factor of about 2.5. That effect, much smaller than a factor of 10, was established once and for all by the study. When the randomized experiment ...
... experiment, definitively demonstrated protection by the vaccine, which cut the polio rate by a factor of about 2.5. That effect, much smaller than a factor of 10, was established once and for all by the study. When the randomized experiment ...
Page 21
... experiments, is largely devoted to devising ways to collect data that reduce statistical variation. One device exploits knowledge about interfering variables by applying regression methods (analysis of covariance). Another chooses ...
... experiments, is largely devoted to devising ways to collect data that reduce statistical variation. One device exploits knowledge about interfering variables by applying regression methods (analysis of covariance). Another chooses ...
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analysis applied assessment assigned authors average calculated called cancer Chapter clinical trials combined comparison considered crossover decision depends described determine discussed disease drug effects Engl England Journal error estimate example expected experiment Figure findings fitted four give given groups Health hospital hypothesis important improvement included increase indicated interpretation interval issues Journal less means measurements ment meta-analysis mortality multiple myocardial infarction N Engl observed original outcome patients percent period population possible present probability problems procedures published questions randomized readers reasons reduce REFERENCES regression relation reported requires response risk sample scientific selection shows significant sometimes specific standard statistical methods subjects Table techniques therapy tion treated treatment usually variables variance Yes Yes