Medical Uses of StatisticsJohn C. Bailar III, Frederick Mosteller CRC Press, 2019 M05 20 - 480 pages This work explains the purpose of statistical methods in medical studies and analyzes the statistical techniques used by clinical investigators, with special emphasis on studies published in "The New England Journal of Medicine". It clarifies fundamental concepts of statistical design and analysis, and facilitates the understanding of research results. |
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Page 7
... assigned stages by the same person, team, or committee? If not, then how were disease stages determined? How reproducible is the staging? For instance, were any cases staged twice and blindly? If laboratory or microscopic confirmation ...
... assigned stages by the same person, team, or committee? If not, then how were disease stages determined? How reproducible is the staging? For instance, were any cases staged twice and blindly? If laboratory or microscopic confirmation ...
Page 8
... assignment of treatment, the care itself (using the assigned treatment and any adjuvant treatments), evaluation of the patient's outcome (perhaps after a follow-up interval), statistical analysis of the data (including the information ...
... assignment of treatment, the care itself (using the assigned treatment and any adjuvant treatments), evaluation of the patient's outcome (perhaps after a follow-up interval), statistical analysis of the data (including the information ...
Page 9
... assignment or results may lead to contamination of the conclusions. INTEGRITY OF OPERATIONAL DEFINITION When we move from studies where the investigators impose treatments to those where they simply observe different groups or similar ...
... assignment or results may lead to contamination of the conclusions. INTEGRITY OF OPERATIONAL DEFINITION When we move from studies where the investigators impose treatments to those where they simply observe different groups or similar ...
Page 19
... assigning treatments to randomly constituted subgroups. First, conditions to be investigated may not be assignable ... assigned to treatment II. (Thus, the initial “suitable group should consist of patients for whom both treatments are ...
... assigning treatments to randomly constituted subgroups. First, conditions to be investigated may not be assignable ... assigned to treatment II. (Thus, the initial “suitable group should consist of patients for whom both treatments are ...
Page 23
... assigned to treatments, what treatments were applied, how outcomes were measured, or in what order these steps were taken. DerSimonian et al.8 reviewed reports of clinical trials published in four leading medical journals. Their ...
... assigned to treatments, what treatments were applied, how outcomes were measured, or in what order these steps were taken. DerSimonian et al.8 reviewed reports of clinical trials published in four leading medical journals. Their ...
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analysis applied assessment assigned authors average calculated called cancer Chapter clinical trials combined comparison considered crossover decision depends described determine discussed disease drug effects Engl England Journal error estimate example expected experiment Figure findings fitted four give given groups Health hospital hypothesis important improvement included increase indicated interpretation interval issues Journal less means measurements ment meta-analysis mortality multiple myocardial infarction N Engl observed original outcome patients percent period population possible present probability problems procedures published questions randomized readers reasons reduce REFERENCES regression relation reported requires response risk sample scientific selection shows significant sometimes specific standard statistical methods subjects Table techniques therapy tion treated treatment usually variables variance Yes Yes