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SCIENCE EDUCATION

Question. If an additional $5,000,000 were provided in FY 1992 for Science Education, how would the NIH utilize these funds?

Answer. If an additional $5 million were made available for FY 1992, NIH would use it to expand its support of the Science Education Partnership Awards (SEPA), to fully implement the AREA Grant Support for Science Teachers program and to fund the implementation of the strategies and action plan developed at the National Conference.

The initial response to the SEPA program has been overwhelming. The program was announced in February of this year and we have already received close to 300 letters of intent from applicants. If additional funds are available, they would be used to support and expand these grants in 1992. The types of activities funded would include:

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Projects improving the scientific knowledge base of current and prospective precollege teachers so that current concepts in health sciences can be integrated into course content, and teachers' instructional skills can be enhanced.

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The development of innovative materials, techniques
and/or curricula consistent with the purposes of this
program in areas where there is a demonstrated lack of
suitable materials and a need for scientific advice.

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Programs that provide laboratory experiences in the biological sciences for students from the kindergarten through the twelfth grade. These programs may be in formal school settings or in community settings. Programs that provide for linkages among PHS-funded scientists and local community and school programs which provide for continued contact/mentoring to encourage pursuit of science careers are particularly desirable.

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Activities which provide training, resources, and
support to encourage and prepare individual
biomedical/behavioral scientists to become involved in
projects to educate the general public about science,
including those aimed at educating parents and their
children. These would include speaking to students,
adults, teachers, or organizations in an informal but
instructive manner in suitable public places where
biological/behavioral science might be presented in a
captivating way to the lay public.

The AREA Grant Support for Science Teachers program will enhance the expertise of high school science teachers by providing funds for them to participate in research being done at Academic Research Enhancement Award (AREA) grant institutions, i.e., institutions that historically have not received major extramural support. Additional funds would be

used to fully develop the program and expand the number of supplements available nationwide.

As was mentioned, the PHS National Conference will bring together experts from across the education community, Federal Government, and private industry to help develop strategies and a long range plan for PHS involvement in science education. The National Institutes of Health, which is providing a large portion of the funding for the conference, will devote any additional available funds to implementing these recommendations.

NATIONAL CANCER INSTITUTE

STATEMENT OF DR. SAMUEL BRODER, DIRECTOR, NATIONAL CANCER

INSTITUTE

BUDGET REQUEST Senator HARKIN. We will call up all the individual directors here, Dr. Broder at the National Cancer Institute; Dr. Lenfant, Heart, Lung, and Blood; Dr. Tony Fauci with Allergy and Infectious Diseases; and Dr. Harald Löe, National Institute of Dental Research. It is my intent to just simply start in the order in which I have it here.

I will start with Dr. Broder, National Cancer Institute. Dr. Broder, the committee has your budget request for $1.8 billion, which is about 5 percent more than last year. I note that more than one-half of your proposed growth for 1992 is for research project grants, while your request for centers and training is essentially flat with a loss of two of your basic research centers. So, Dr. Broder, could you please give us a brief statement in support of your request, as well as any scientific highlights that you would care to make?

OPENING REMARKS

Dr. BRODER. Thank you very much. Sir, it is my great honor to be here.

This year has been marked by high scientific achievement for the National Cancer Program. The National Cancer Institute [NCI] has pioneered methods of rapid communication about advances in clinical research and continues to disseminate state-of-the-art information in the United States and throughout the world. New cancer drugs have been developed and new prevention strategies using vitamin derivatives have proven effective.

Scientists from NCI and the National Heart, Lung, and Blood Institute have pioneered gene treatment studies. Last year, studies successfully traced the activity of new genes in reinfused cells into patients, and a related study introduced gene therapy for an extremely unusual but important inherited immune system disorder caused by the absence of the enzyme adenosine deaminase, called ADAPreliminary results in the first patient, a 4-year-old girl, suggested her immune function has, in fact, improved and, therefore, we would declare this the first successful, or at least experimentally successful, application of genetic engineering in the form of gene transfer therapy. The results are still preliminary and they cannot be taken to be a final answer, but we do believe that this is an important advance.

Most recently two patients with melanoma, a form of skin cancer that is quite virulent and often lethal, were treated with special tumor infiltrating lymphocytes armed with a gene that produces a potent antitumor agent, tumor necrosis factor, and this again is a result of the gene transfer technology that we were discussing:

Major progress has been made in reducing deaths from childhood cancers and in preventing or treating many common cancers in adults as well. However, there has been less progress in reducing the death rate from common solid tumors in patients age 65 and over. Many Americans, the poor, the underserved and members of some minority groups do not have access to state-of-the-art prevention, early diagnosis and treatment, and have disproportionately high cancer incidence and mortality rates. We must increase our efforts in cancer prevention and control.

Research on cancers that affect women is a high priority for the National Cancer Institute as cancer is the second leading cause of death among women in the United States with more than 150,000 women expected to die in 1991 of cancers of the lung, breast, colon, and reproductive tract.

NCI supported scientists are unraveling the genetic mysteries of the cancer cell and important new theories of how cancer evolves from the normal cell are emerging with increasing information about oncogenes and suppressor genes.

The NCI cancer centers program provides interdisciplinary cancer research and state-of-the-art diagnosis, treatment and rehabilitation, prevention, and cancer control, as well as community outreach and research on a number of cancers, including AIDS-related cancers, throughout the Nation.

Additionally, NCI's ability to transfer technology effectively rests on community programs such as the clinical cooperative groups and the community clinical oncology program which we refer to as our CCOP program. The latter are especially important in getting state-of-the-art treatment to rural areas, and we now have active participation in NCI funded clinical trials in many small towns throughout the country, some with wonderful names like Spirit Lake, Royal, and Rembrandt.

Among other new cancer drugs, there is a great interest in taxol as it can kill various cancer cells. This is an important drug. It is derived from the bark of yew trees and is in very short supply, but NCI is undertaking taxol development from alternative renewable resources. This is an important and, in fact, an emergency priority of the Institute.

Prevention is the most effective way to eliminate a disease, and NCI is studying smoking cessation, diet, chemoprevention, cancer vaccines, and the use of special hormones to prevent tumors.

The NCI has assisted in evaluating potential environmental issues such as those related to nuclear powerplant facilities.

The NCI also has an important mission in AIDS research, and works closely with other Federal agencies. While not the lead agency at the National Institutes of Health, the NCI is proud of its supporting role. NCI scientists have made vital contributions in areas such as basic biomedical research on the pathogenesis and natural history of the Human Immunodeficiency Virus (HIV). We have drug development programs and vaccine development programs. The NCI intramural program is a leader in developing new therapies for children with AIDS and pediatric research in AIDS is an important priority of the institute. As people with AIDS are surviving longer, the incidence of AIDS related cancers is increasing, and NCI is working to meet this challenge.

PREPARED STATEMENT One measure of the success of the National Cancer Act is that there are over 6 million survivors in the United States, people who have had cancer and who have survived. We have accrued a new understanding of the basic biology of cancer which in turn is pointing to effective prevention, diagnosis, and treatment. We must continue our progress, and the NCI stands to fulfill that goal.

Mr. Chairman, the 1992 budget request for the Institute totals $1,810,230,000.

I would be very pleased to answer any questions. [The statement follows:]

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