High Throughput Analysis for Early Drug DiscoveryJames Kyranos Elsevier, 2004 M09 18 - 204 pages High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity.
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From inside the book
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Page v
... Molecular Tags 1 Introduction 2 Tag Decode-Assisted Single Bead LC/MS Analysis (Library QA) 3 Statistical Considerations 4 Synthesis of the Encoded Statine Amide Library 5 Biological Screening 6 Corroborating Screening Structure ...
... Molecular Tags 1 Introduction 2 Tag Decode-Assisted Single Bead LC/MS Analysis (Library QA) 3 Statistical Considerations 4 Synthesis of the Encoded Statine Amide Library 5 Biological Screening 6 Corroborating Screening Structure ...
Page ix
... molecular structure either before or after screening and use the information to follow up with synthetic modifications to parts of the molecule that appear to regulate potency, selectivity or any other parameter that needs to be ...
... molecular structure either before or after screening and use the information to follow up with synthetic modifications to parts of the molecule that appear to regulate potency, selectivity or any other parameter that needs to be ...
Page x
... molecular structure in the case of MS and a tradition with significant experience in automated unattended runs, which addresses the high throughput need. Moreover, the flexibility and adaptability of chromatography and mass spectrometry ...
... molecular structure in the case of MS and a tradition with significant experience in automated unattended runs, which addresses the high throughput need. Moreover, the flexibility and adaptability of chromatography and mass spectrometry ...
Page xiii
... Molecular Research, Inc. 18804 North Creek Parkway Bothell, WA 98011 Email: cheryl.garrøalbmolecular.com Samuel W. Gerritz, Ph.D. Bristol-Myers Squibb 5 Research Parkway Wallingford, CT 06492 Email: samuel gerritzøbms.com Michael C ...
... Molecular Research, Inc. 18804 North Creek Parkway Bothell, WA 98011 Email: cheryl.garrøalbmolecular.com Samuel W. Gerritz, Ph.D. Bristol-Myers Squibb 5 Research Parkway Wallingford, CT 06492 Email: samuel gerritzøbms.com Michael C ...
Page 1
James Kyranos. 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags Ian Henderson, Joan Guo, Lawrence W. Dillard and Mary M. Sherman Pharmacopeia, Inc., P.O. Box ... Molecular Tags 1. Introduction.
James Kyranos. 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags Ian Henderson, Joan Guo, Lawrence W. Dillard and Mary M. Sherman Pharmacopeia, Inc., P.O. Box ... Molecular Tags 1. Introduction.
Contents
Chapter 2 Analysis of a Combinatorial Library Synthesized Using a SplitandPool Irori MicroKan Method for Development and Production | 37 |
Chapter 3 High Throughput Flow Injection AnalysisMass Spectrometry | 57 |
Chapter 4 High Throughput Flow Injection AnalysisMass Spectrometry for Combinatorial Chemistry Using Electrospray Ionization Atmospheric Pres... | 73 |
Chapter 5 Purity and Quantity Determination of Parallel Synthesis Compound Libraries | 95 |
Chapter 6 High Throughput Parallel LCMSELSD of Combinatorial Libraries Using the EightChannel LCT System with MUX Technology | 113 |
Chapter 7 Purification and Analysis of Parallel Libraries | 125 |
Chapter 8 Screening SingleBead Combinatorial Libraries using Capillary HPLC and MALDITOFMS | 147 |
Chapter 9 The Role of NMR in the Analysis of Chemical Libraries | 163 |
Subject Index | 183 |
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Common terms and phrases
acid activity addition allow amount Anal analysis analytical APCI application approach approximately automated autosampler beads channel characterization Chem chemical chromatography CO2H collection column combination combinatorial chemistry combinatorial libraries components compounds concentration confirmation containing decoded designed detection determined drug ELSD error example experimental Figure final flow four fractions high throughput HPLC identified increase individual initial injection ionization mass spectral mass spectrometer material methods molecular molecules observed obtained optimization overall parallel peak performance phase plate positive possible prepared present problem purification purity quantity racks range Rapid reaction reagent response sample screening selected separation shown shows single solvent sort spectra Spectrom standard step structures synthesis synthons Table techniques test tubes trace typically weight yield
Popular passages
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