High Throughput Analysis for Early Drug DiscoveryJames Kyranos Elsevier, 2004 M09 18 - 204 pages High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity.
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From inside the book
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Page vi
... 59 59 61 62 65 67 70 70 70 73 74 Contents 5 Conclusions Acknowledgements References Purity and Quantity Determination of. 74 75 77 78 82 82 84 85 86 88 88 90 CEPTYR, Inc. 3830 Monte Villa Parkway Bothell, WA 98021 Andrea vi Contents.
... 59 59 61 62 65 67 70 70 70 73 74 Contents 5 Conclusions Acknowledgements References Purity and Quantity Determination of. 74 75 77 78 82 82 84 85 86 88 88 90 CEPTYR, Inc. 3830 Monte Villa Parkway Bothell, WA 98021 Andrea vi Contents.
Page vii
... Determination Fast Chromatography High Throughput HPLC/Mass Spectrometry Data Management Experimental Methods 9.1 Sample Introduction 9.2 HPLC Instrumentation 9.3 MS Instrumentation 9.4 Analytical Standards 9.5 ELSD Quantity Determination ...
... Determination Fast Chromatography High Throughput HPLC/Mass Spectrometry Data Management Experimental Methods 9.1 Sample Introduction 9.2 HPLC Instrumentation 9.3 MS Instrumentation 9.4 Analytical Standards 9.5 ELSD Quantity Determination ...
Page x
... determined by the synthesis methodology and the final form of the compounds of interest. For instance, if one were to synthesize libraries on solid supports using mix-and-split techniques, the final analytical methodology would have to ...
... determined by the synthesis methodology and the final form of the compounds of interest. For instance, if one were to synthesize libraries on solid supports using mix-and-split techniques, the final analytical methodology would have to ...
Page 3
... determined."" This may be accomplished by employing routine HPLC analysis coupled singularly or in combination with UV," "evaporative lightscattering detection (ELSD)," " chemiluminescent nitrogen detection (CLND),76–78 MS,79–89 ...
... determined."" This may be accomplished by employing routine HPLC analysis coupled singularly or in combination with UV," "evaporative lightscattering detection (ELSD)," " chemiluminescent nitrogen detection (CLND),76–78 MS,79–89 ...
Page 4
... determine its molecular weight. Comparing the molecular weight predicted by the tag decode with the empirical value yields a “yes/no” answer corroborating the presence or absence of the inferred compound. Statistical sampling of several ...
... determine its molecular weight. Comparing the molecular weight predicted by the tag decode with the empirical value yields a “yes/no” answer corroborating the presence or absence of the inferred compound. Statistical sampling of several ...
Contents
Chapter 2 Analysis of a Combinatorial Library Synthesized Using a SplitandPool Irori MicroKan Method for Development and Production | 37 |
Chapter 3 High Throughput Flow Injection AnalysisMass Spectrometry | 57 |
Chapter 4 High Throughput Flow Injection AnalysisMass Spectrometry for Combinatorial Chemistry Using Electrospray Ionization Atmospheric Pres... | 73 |
Chapter 5 Purity and Quantity Determination of Parallel Synthesis Compound Libraries | 95 |
Chapter 6 High Throughput Parallel LCMSELSD of Combinatorial Libraries Using the EightChannel LCT System with MUX Technology | 113 |
Chapter 7 Purification and Analysis of Parallel Libraries | 125 |
Chapter 8 Screening SingleBead Combinatorial Libraries using Capillary HPLC and MALDITOFMS | 147 |
Chapter 9 The Role of NMR in the Analysis of Chemical Libraries | 163 |
Subject Index | 183 |
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Common terms and phrases
acid activity addition allow amount Anal analysis analytical APCI application approach approximately automated autosampler beads channel characterization Chem chemical chromatography CO2H collection column combination combinatorial chemistry combinatorial libraries components compounds concentration confirmation containing decoded designed detection determined drug ELSD error example experimental Figure final flow four fractions high throughput HPLC identified increase individual initial injection ionization mass spectral mass spectrometer material methods molecular molecules observed obtained optimization overall parallel peak performance phase plate positive possible prepared present problem purification purity quantity racks range Rapid reaction reagent response sample screening selected separation shown shows single solvent sort spectra Spectrom standard step structures synthesis synthons Table techniques test tubes trace typically weight yield
Popular passages
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