High Throughput Analysis for Early Drug DiscoveryJames Kyranos Elsevier, 2004 M09 18 - 204 pages High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity.
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Page v
James Kyranos. Contents Preface List of Contributors Acknowledgments 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags 1 Introduction 2 Tag Decode-Assisted Single Bead LC/MS Analysis (Library ...
James Kyranos. Contents Preface List of Contributors Acknowledgments 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Molecular Tags 1 Introduction 2 Tag Decode-Assisted Single Bead LC/MS Analysis (Library ...
Page vii
... Libraries Introduction Library Development and Production Analytical Process Purity Assessment Quantity ... Combinatorial Libraries Using the Eight-Channel LCT System with MUX Technology 1 Introduction 2 Experimental 3 Results and ...
... Libraries Introduction Library Development and Production Analytical Process Purity Assessment Quantity ... Combinatorial Libraries Using the Eight-Channel LCT System with MUX Technology 1 Introduction 2 Experimental 3 Results and ...
Page viii
... Combinatorial Libraries using Capillary HPLC and MALDI-TOF-MS 147 1 Introduction 147 1.1 HPLC Separations 149 1.2 Hyphenation of MALDI and HPLC 151 1.3 Mass Spectrometric Analysis 153 2 Future Trends 157 3 Conclusion 160 References 160 ...
... Combinatorial Libraries using Capillary HPLC and MALDI-TOF-MS 147 1 Introduction 147 1.1 HPLC Separations 149 1.2 Hyphenation of MALDI and HPLC 151 1.3 Mass Spectrometric Analysis 153 2 Future Trends 157 3 Conclusion 160 References 160 ...
Page x
... libraries on solid supports using mix-and-split techniques, the final analytical methodology would have to ... combinatorial chemistry using mix-and-split methodologies and reviews the analytical approach of encoding and decoding ...
... libraries on solid supports using mix-and-split techniques, the final analytical methodology would have to ... combinatorial chemistry using mix-and-split methodologies and reviews the analytical approach of encoding and decoding ...
Page xvii
... when much of my time was focused on this project and would like to dedicate this book to them as a small token of my appreciation of them. 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Acknowledgments.
... when much of my time was focused on this project and would like to dedicate this book to them as a small token of my appreciation of them. 1 High Throughput Analysis of Combinatorial Libraries Encoded with Electrophoric Acknowledgments.
Contents
Chapter 2 Analysis of a Combinatorial Library Synthesized Using a SplitandPool Irori MicroKan Method for Development and Production | 37 |
Chapter 3 High Throughput Flow Injection AnalysisMass Spectrometry | 57 |
Chapter 4 High Throughput Flow Injection AnalysisMass Spectrometry for Combinatorial Chemistry Using Electrospray Ionization Atmospheric Pres... | 73 |
Chapter 5 Purity and Quantity Determination of Parallel Synthesis Compound Libraries | 95 |
Chapter 6 High Throughput Parallel LCMSELSD of Combinatorial Libraries Using the EightChannel LCT System with MUX Technology | 113 |
Chapter 7 Purification and Analysis of Parallel Libraries | 125 |
Chapter 8 Screening SingleBead Combinatorial Libraries using Capillary HPLC and MALDITOFMS | 147 |
Chapter 9 The Role of NMR in the Analysis of Chemical Libraries | 163 |
Subject Index | 183 |
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Common terms and phrases
acid activity addition allow amount Anal analysis analytical APCI application approach approximately automated autosampler beads channel characterization Chem chemical chromatography CO2H collection column combination combinatorial chemistry combinatorial libraries components compounds concentration confirmation containing decoded designed detection determined drug ELSD error example experimental Figure final flow four fractions high throughput HPLC identified increase individual initial injection ionization mass spectral mass spectrometer material methods molecular molecules observed obtained optimization overall parallel peak performance phase plate positive possible prepared present problem purification purity quantity racks range Rapid reaction reagent response sample screening selected separation shown shows single solvent sort spectra Spectrom standard step structures synthesis synthons Table techniques test tubes trace typically weight yield
Popular passages
Page 118 - ... [(a - b + c) - (d + e + f)] + [g - (h - ¡)] = (- a + b) + (-c + d...
Page xvi - And finally, I would like to thank my wife and children for their great patience throughout the long period of writing this book.
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