High Throughput Analysis for Early Drug DiscoveryJames Kyranos Elsevier, 2004 M09 18 - 204 pages High Throughput Analysis for Early Drug Discovery offers concise and unbiased presentations by synthetic and analytical chemists who have been involved in creating and moving the field of combinatorial chemistry into the academic and industrial mainstream. Since the synthetic method often dictates the appropriate types of analysis, each chapter or section begins with a description of the synthesis approach and its advantages. The description of various combinatorial and high-throughput parallel synthesis techniques provide a relevant point of entry for synthetic chemists who need to set up appropriate characterisation methods for his/her organisation. This is an invaluable resource for all organic and analytical chemists in the pharmaceutical, agrochemical, and biotechnology fields who are either involved in, or beginning to investigate combinatorial techniques to increase overall efficiency and productivity.
|
From inside the book
Results 1-5 of 44
Page v
... 2.1 Single-Channel HPLC/UV/ELSD/MS System 2.2 Four-Channel Multiplexed HPLC/UV/ELSD/MS System 3 Data Processing ix xiii xvii 1 . 21 23 33 33 37 38 39 39 40 41 4 Automated SPE System in 96-Well Plate Format 5 Results Contents.
... 2.1 Single-Channel HPLC/UV/ELSD/MS System 2.2 Four-Channel Multiplexed HPLC/UV/ELSD/MS System 3 Data Processing ix xiii xvii 1 . 21 23 33 33 37 38 39 39 40 41 4 Automated SPE System in 96-Well Plate Format 5 Results Contents.
Page vi
James Kyranos. 4 Automated SPE System in 96-Well Plate Format 5 Results and Discussion 6 Library Development Stage 7 Library Production Stage 8 High Throughput Purification using SPE 9 100% QC by LC/UV/ELSD/MS and Analytical Reports 10 ...
James Kyranos. 4 Automated SPE System in 96-Well Plate Format 5 Results and Discussion 6 Library Development Stage 7 Library Production Stage 8 High Throughput Purification using SPE 9 100% QC by LC/UV/ELSD/MS and Analytical Reports 10 ...
Page viii
... Automation Technology for Sample Handling 174 10 NMR Data Analysis 175 11 Case Study 3: Analysis of 96 Benzoylated Amines 176 12 Conclusion 180 Acknowledgements 181 References 181 Subject Index 183 Preface During the last two decades ...
... Automation Technology for Sample Handling 174 10 NMR Data Analysis 175 11 Case Study 3: Analysis of 96 Benzoylated Amines 176 12 Conclusion 180 Acknowledgements 181 References 181 Subject Index 183 Preface During the last two decades ...
Page ix
... automation to name just a few. Combinatorial and high throughput parallel synthesis chemistry have been the most recent potential levers developed to bridge the early discovery productivity gap. Although initial debate focused on the ...
... automation to name just a few. Combinatorial and high throughput parallel synthesis chemistry have been the most recent potential levers developed to bridge the early discovery productivity gap. Although initial debate focused on the ...
Page x
... automated unattended runs, which addresses the high throughput need. Moreover, the flexibility and adaptability of chromatography and mass spectrometry have contributed to the preferential selection of these techniques to support high ...
... automated unattended runs, which addresses the high throughput need. Moreover, the flexibility and adaptability of chromatography and mass spectrometry have contributed to the preferential selection of these techniques to support high ...
Contents
Chapter 2 Analysis of a Combinatorial Library Synthesized Using a SplitandPool Irori MicroKan Method for Development and Production | 37 |
Chapter 3 High Throughput Flow Injection AnalysisMass Spectrometry | 57 |
Chapter 4 High Throughput Flow Injection AnalysisMass Spectrometry for Combinatorial Chemistry Using Electrospray Ionization Atmospheric Pres... | 73 |
Chapter 5 Purity and Quantity Determination of Parallel Synthesis Compound Libraries | 95 |
Chapter 6 High Throughput Parallel LCMSELSD of Combinatorial Libraries Using the EightChannel LCT System with MUX Technology | 113 |
Chapter 7 Purification and Analysis of Parallel Libraries | 125 |
Chapter 8 Screening SingleBead Combinatorial Libraries using Capillary HPLC and MALDITOFMS | 147 |
Chapter 9 The Role of NMR in the Analysis of Chemical Libraries | 163 |
Subject Index | 183 |
Other editions - View all
Common terms and phrases
acid activity addition allow amount Anal analysis analytical APCI application approach approximately automated autosampler beads channel characterization Chem chemical chromatography CO2H collection column combination combinatorial chemistry combinatorial libraries components compounds concentration confirmation containing decoded designed detection determined drug ELSD error example experimental Figure final flow four fractions high throughput HPLC identified increase individual initial injection ionization mass spectral mass spectrometer material methods molecular molecules observed obtained optimization overall parallel peak performance phase plate positive possible prepared present problem purification purity quantity racks range Rapid reaction reagent response sample screening selected separation shown shows single solvent sort spectra Spectrom standard step structures synthesis synthons Table techniques test tubes trace typically weight yield
Popular passages
Page 118 - ... [(a - b + c) - (d + e + f)] + [g - (h - ¡)] = (- a + b) + (-c + d...
Page xvi - And finally, I would like to thank my wife and children for their great patience throughout the long period of writing this book.
Page 54 - EJ Moran, S. Sarshar, JF Cargill, MM Shahbaz, A. Lio, AMM Mjalli, and RW Armstrong, J. Am. Chem. Soc., 117, 10787 (1995).
Page 33 - HM Geysen, CD Wagner, WM Bodnar, CJ Markworth, GJ Parke, FJ Schoenen, DS Wagner, DS Kinder.
Page ix - The aim of this book is to provide the reader with an understanding of the ways in which drylands have been managed and developed.
Page 54 - T. Wang, L. Zeng, T. Strader, L. Burton and DB Kassel, Rapid Commun. Mass Spectrom., 12 (1998) 1123.
Page 70 - Z. Shen, JJ Thomas, C. Averbuj, KM Broo, M. Engelhard, JE Crowell, MG Finn, G. Siuzdak. Anal. Chem.
Page 34 - JM Ostresh, GM Husar, SE Blondelle, B. Dorner, PA Weber, and RA Houghten, Proc.
Page 33 - WL Fitch, TA Baer, W. Chen, F. Holden, CP Holmes, D. Maclean, N. Shah, E. Sullivan, M. Tang, P. Waybourn, SM Fischer, CA Miller and LR Snyder, J. Comb. Chem., 1 (1999) 188.
Page 69 - PA Keifer, SH Smallcombe, EH Williams, KE Salomon, G. Mendez, JL Belletire and CD Moore.