Results have shown the parainfluenza vaccines to be effective. A trivalent parainfluenza vaccine (combining types 1, 2, and 3) has been produced, and combinations made with still other vaccines. The potential of certain respiratory viruses to cause tumor formation in experimental animals continues to require an intensive effort to prevent the use of oncogenically contaminated virus strains. In 1968, there will be increased procurement and testing of experimental lots of vaccines for clinical trials. Work on the preparation of vaccines for the rhinoviruses which are the main causative agent of the common cold will be increased. An increase of 1 position and $552,000 is requested in 1968 over 1967. In 1967, the Reference Reagents Program has emphasized (1) completion of reference reagents production for those accepted viral prototypes of the adeno, myxo, entero, and herpes virus groups; (2) continued production, testing and certification of both type specific and grouping reagents for arboviruses; (3) continuation of the production, testing and certification of human and animal mycoplasma reagents in a cooperative effort with Division of Biologics Standards; (4) planning and initiating rhinovirus reagent production, testing and certification; and (5) pilot studies on the methodology for improved ampuling, packaging, and storing of labile reference reagents. In 1968, primary emphasis will be on (1) facilitating and expediting production of vitally needed rhinovirus and arbovirus reference reagents; (2) conducting an intensive research and development program an lyophilization and storage of reference reagents; (3) re-examining research reference reagents produced under previous contracts now in the repository to determine viability, titers, etc., and presence of contaminants now detectable by methods not previously available, and planning and initiating production of replacement reagents where indicated; (4) studying and developing improved methodology in the production of antiserum, concentrating on such factors as the type and quality of animals used, the nature of antigens and adjuvants, immunization schedules and routes of injection; and (5) planning, developing, and initiating production of reagents to those additional organisms causing infectious and parasitic disease, in response to needs for other standardized microbial reagents not commercially available. Included in this net increase is $13,000 for annualization of positions new in 1967 offset by one less day of pay in 1968. There is also an increase of $6,000 for services furnished centrally by the National Institutes of Health management fund. Biomelry, Epidemiology, and Field Studies Biometry, Epidemiology, and Field Studies are primarily related to insect transmitted virus diseases as represented by the Middle America Research Unit in the Panma Canal Zone, and the arbovirus research program at the Rocky Mountain Laboratory. These activities have also been identified as important ingredients in the U.S. element of the U.S.-Japan Cooperative Medical Science Program of arbovirus research and provide support in the form of project officers to the Reference Reagents Program of the Institute. Other epidemiology and field studies relate to respiratory diseases in an institutional population where new causative agents are being sought and to studies on certain fungus and leptospiral infections in Panama. Of the net increase, $60,000 is requested to take care of the increased costs of maintaining current levels of support for operating costs and $7,000 for centrally furnished services from the National Institutes of Health management fund. This activity provides for the over-all coordination and administration of the Institute's grants programs. The activity is responsible for planning and developing scientific programs for research and training grants and fellowship awards. This involves the collection, processing, review and evaluation of applications; support of the National Advisory Allergy and Infectious Disease Council; liaison with appropriate organizations and scientists, continual vigilance by professional staff of program progress on scientific activities; and surveillance by supporting personnel on recording and reporting of varied information concerning grants management. The requested program increase of $28,000 will provide for increased operating costs. Included in the net increase requested is $1,000 for annualization of a position new in 1967, offset by one less day of pay in 1968. There is also an increase of $95,000 for centrally furnished services from the National Institutes of Health management fund. This activity supports the Institute Director and his immediate staff in the over-all administration, coordination and direction of all the Institute's activities. The requested program increase of $7,000 will provide for increased operating costs. Included in this net increase is $2,000 for annualization of a position new in 1967, offset by one less day of pay in 1968. There is also an increase of $4,000 for centrally furnished services from the National Institutes of Health management fund. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES LIST OF WITNESSES DR. FREDERICK L. STONE, DIRECTOR, NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES DR. JAMES A. SHANNON, DIRECTOR, NATIONAL INSTITUTES OF HEALTH GORDON J. KLOVDAHL, EXECUTIVE OFFICER, NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES MRS. EMMA LOU AKERS, BUDGET OFFICER, NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES RICHARD L. SEGGEL, EXECUTIVE OFFICER, NATIONAL INSTITUTES OF HEALTH CHARLES MILLER, FINANCIAL MANAGEMENT OFFICER, NATIONAL INSTITUTES OF HEALTH DR. WILLIAM H. STEWART, SURGEON GENERAL G. R. CLAGUE, ACTING CHIEF FINANCE OFFICER JAMES B. CARDWELL, DEPUTY ASSISTANT SECRETARY, BUDGET 1 Includes capital outlay as follows: 1966, $36,000; 1967, $79,000; and 1968, $60,000. Selected resources as of June 30 are as follows: Unpaid undelivered orders, 1965, $0; 1966, $2,727,000; 1967, $2,915,000; 1968, $3,014,000. BIOGRAPHICAL SKETCH OF PRINCIPAL WITNESS Name: Frederick L. Stone. Position Director, National Institute of General Medical Sciences. Education: 1937, Middlebury College, Middlebury, Vermont (Chemistry), B. S.; 1942, University of Rochester, Rochester, N.Y. (Biology), M.S.; 1948, University of Rochester, Rochester, N.Y. (Biology), Ph. D.; 1949–53, American University, Washington, D.C. (Public Administration). Experience: August 1964 to present, Director, National Institute of General Medical Sciences, National Health Institutes of Health; July 1962 to August 1964, Chief, Division of Research Facilities and Resources, NIH; January to July 1962, Acting Chief, Division of General Medical Sciences, NIH; 19581962, Assistant Chief, Division of General Medical Sciences, and Chief, Research Training Branch, DGMS, NIH; 1957-1958, Assistant Chief, Division of Research Grants, and Chief, Research Training Branch, DRG, NIH; 19561957, Assistant to the Associate Director, NIH; 1955-1956, Director, Medical and Scientific Department, National Multiple Sclerosis Society, New York; 1954-1955, Assistant for Professional Services to the Vice-Chancellor, Schools of the Health Professions, University of Pittsburgh, Pittsburgh, Pa.; 19511954, Chief, Extramural Programs, National Institute of Neurological Diseases and Blindness, NIH; 1948-1951, Chief, Research Fellowships Branch, Division of Research Grants, NIH; 1947-1948, Instructor in Biology, University of Rochester, Rochester, N.Y. Association memberships: American Association of Medical Colleges; American Association for the Advancement of Science; American Academy of Neurology; American Society of Ichthyology and Herpetology; American Historical Society (ISIS); Association for Research in Nervous and Mental Diseases; Association for Research in Ophthalmology; Cosmos Club, Washington, D.C.; Sigma Xi; the Royal Society of Medicine (Affiliate). Special awards and citations: Superior Service Award, Department of Health, Education, and Welfare, April 10, 1964; the Secretary's Special Citation, Department of Health, Education, and Welfare, January 1966. Mr. FLOOD. Our next witness is Dr. Frederick L. Stone, Director of the National Institute of General Medical Sciences. Dr. Stone, would you proceed with your statement? GENERAL STATEMENT Dr. STONE. Mr. Chairman and members of the committee, it is a privilege to appear before you on behalf of the National Institute of General Medical Sciences in connection with the appropriations for fiscal year 1968. I welcome especially the opportunity to tell the new members of this committee something about this Institute, its development, major areas of emphasis, and its key activities. RATIONALE FOR INSTITUTE FOR GENERAL MEDICAL SCIENCES Most of the National Institutes of Health's categorical or, as they are sometimes called, disease-oriented, Institutes were established in the late 1940's or early 1950's. Despite the need for a fundamental scientific underpinning for the more practical activities in each Institute, it was soon evident that a more general organization was needed to assure stable growth for a number of scientific areas such as biochemistry, pharmacology, genetics, and biophysics, which, though essential to the growth of each of the categorical programs, are general in nature and therefore could not be expected to flourish without some central point of scrutiny and support. It was the need for such a central concern that resulted in the development of the National Institute of General Medical Sciences. Very early it became apparent that certain general clinical areas, for example, anesthesiology and surgery, which are important to many of the categorical programs, could also profit by being the responsibility of such a central operation. 78-317-67-pt. 5-38 |