rejection of the individual to this foreign material is concerned, whether it be the tooth that was extracted and then replaced in the same person, the so-called autogenous implant or transplant, versus the implantation from another subject of the same species, a so-called heterogenous transplant. The greatest impetus to our current progress has been the collaboration between the immunologist, the dental scientist, the biochemist, the wideranging numbers of scientific disciplines that can all pool their talents and hopefully come up with a material that would surmount this barrier of an immunological or rejection response. The Hodash study referred to earlier at Brown University is one whereby they use a polymer structure, a material that would reproduce in anatomical form the tooth that has been lost. This is replaced in the socket of the individual or the animal that has lost its natural tooth. As of this time, using principally the baboon, the success has been quite remarkable. We hope that in the early years ahead, and possibly even as early as the next fiscal year, trials might be made on the human subject; carefully controlled studies whereby this technique might be proven to be applicable to man. Mr. NATCHER. Thank you, Doctor. Mr. FLOOD. Mr. Casey? Mr. CASEY. I have no questions. Mr. FLOOD. Thank you very much. Dr. KRESHOVER. Thank you, Mr. Chairman. JUSTIFICATION MATERIAL NATIONAL INSTITUTE OF DENTAL RESEARCH Amounts available for obligation Appropriation Transfer to "Operating expenses, Public Buildings Service," General Serv- Comparative transfer to "Salaries and expenses, Office of the Secretary". Total. Grants: Obligations by activities Summary of changes 1967 enacted appropriation----. Transferred to “Operating expenses, Public Buildings Services," Comparative transfer to "Salaries and expenses, Office of the $28, 308, 000 -12,000 -91, 000 +242, 000 - 43,000 28, 404, 000 30, 307, 000 +1, 903, 000 EXPLANATION OF CHANGES Research grants-The increase of $783,000 includes $215,000 for general research support grants, $288,000 for noncompeting requirements of the regular program and $280,000 for competing projects. Fellowships-The increase of $280,000 will provide funds for 25 additional awards. Training-The increase of $71,000 will provide funds for 2 additional grants in the dental graduate program. Laboratory and clinical research-The increase of $388,000 and 6 positions will allow for expansion of research in dental caries and oral and related diseases. Collaborative research and development-The increase of $147,000 and one position will allow for expansion of research and development of an adhesive dental restorative material. Biometry, epidemiology and field studies-The increase of $6,000 will support increased operating expenses. Review and approval of grants-The increase of $23,000 will support increased operating expenses. Program direction-The increase of $7,000 will support increased operating expenses. AUTHORIZING LEGISLATION The legislative authority in Section 301 of the Public Health Service Act which provides for the award of grants for research, research training, and fellowships is included in the section of the justifications under the tab, "Preamble Paragraph" in Volume V. The Public Health Service Act, Title IV, National Research Institutes, Part C, National Institute of Dental Research "SEC. 421. There is hereby established in the Public Health Service a National Institute of Dental Research (hereafter in this part referred to as the 'Institute'). "SEC. 422. In carrying out the purposes of section 301 with respect to dental diseases and conditions the Surgeon General, through the Institute and in cooperation with the National Advisory Dental Research Council (hereafter in this part referred to as the 'Council'), shall— "(a) conduct, assist, and foster researches, investigations, experiments, and studies relating to the cause, prevention, and methods of diagnosis and treatment of dental diseases and conditions; "(c) provide fellowships in the Institute from funds appropriated or donated for the purpose; "(f) provide training and instruction and establish and maintain traineeships, in the Institute and elsewhere in matters relating to the diagnosis, prevention, and treatment of dental diseases and conditions with such stipends and allowances (including travel and subsistence expenses) for trainees as he may deem necessary, the number of persons receiving such training and instruction, and the number of persons holding such traineeships, to be fixed by the Council, and, in addition, provide for such training, instruction and traineeships through grants, upon recommendation of the Council, to public and other nonprofit institutions." |