Developmental ToxicologyCaroleAKimmel CRC Press, 1994 M06 30 - 479 pages The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology. |
From inside the book
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Contents
Mechanisms of Early | 15 |
Past Present | 53 |
Neuroendocrine | 65 |
Role in Developmental | 85 |
Developmental Immunotoxicology | 93 |
Functional Toxicity in the Developing Heart Lung | 119 |
Relationships Between Maternal and Developmental | 189 |
PharmacokineticPharmacodynamic Approaches | 215 |
Preconception and Postconception | 307 |
Genetic Factors in Clinical Developmental Toxicology | 333 |
Statistical Analysis of Developmental Toxicity Data | 349 |
DoseResponse Modeling | 363 |
Testing of Pharmaceutical Agents for Reproductive | 379 |
Testing of Environmental Agents for Developmental | 403 |
Risk Assessment for Developmental Toxicity | 429 |
455 | |
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Common terms and phrases
abnormal acid activity adult adverse agents alterations animals benzo(a)pyrene biochemical Biol birth cadmium cardiac cells cellular chemical chick embryo chromosome concentration congenital Dawley rats decreased developmental toxicity developmental toxicology dinoseb dose drug effects embryo Environ Health environmental enzyme ethanol evaluation experimental exposed factors fetal weight fetus fetuses function gene gentamicin gestation gestational days glucocorticoids growth hormone guidelines heart human immune system increased induced inhibition injection Kavlock RJ kidney levels litter liver malformations maternal toxicity maturation mechanisms metabolism metallothionein methylmercury mg/kg mice Miller RK morphologic mouse neonatal neural nitrofen normal offspring organ Pediatr Res perinatal pharmacokinetics phenytoin Physiol physiological placenta plasma postnatal potential pregnancy protein pulmonary pups rabbit receptor renal reproductive toxicity response risk assessment Slotkin somatostatin specific surfactant syndrome T-2 toxin teratogenesis teratogenic Teratology thymic thymocytes tion tissue toxicity studies Toxicol Appl Pharmacol treatment utero valproic acid vitro weight xenobiotics yolk sac