Developmental Toxicology

Front Cover
CaroleAKimmel
CRC Press, 1994 M06 30 - 479 pages
The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.

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Contents

Mechanisms of Early
15
Past Present
53
Neuroendocrine
65
Role in Developmental
85
Developmental Immunotoxicology
93
Functional Toxicity in the Developing Heart Lung
119
Relationships Between Maternal and Developmental
189
PharmacokineticPharmacodynamic Approaches
215
Preconception and Postconception
307
Genetic Factors in Clinical Developmental Toxicology
333
Statistical Analysis of Developmental Toxicity Data
349
DoseResponse Modeling
363
Toxicity
379
Testing of Environmental Agents for Developmental
403
Risk Assessment for Developmental Toxicity
429
Subject Index
455

Issues and Approaches in Human Developmental
287

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