The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.
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Mechanisms of Early
Role in Developmental
Functional Toxicity in the Developing Heart Lung
Relationships Between Maternal and Developmental
Preconception and Postconception
Genetic Factors in Clinical Developmental Toxicology
Statistical Analysis of Developmental Toxicity Data
Testing of Environmental Agents for Developmental
Risk Assessment for Developmental Toxicity
Issues and Approaches in Human Developmental
Other editions - View all
abnormal acid activity addition adult adverse agents alterations animals appear Appl approach assessment associated birth blood body brain cadmium cardiac cause cells changes chemical chick concentration decreased defects described determine developmental toxicity disease dose drug early effects embryo Environ environmental evaluation examined example experimental exposed exposure expression factors fetal fetus function gene gestation growth Health heart hormone human immune important increased indicate induced injection kidney lead levels lung malformations maternal maturation measured mechanisms mg/kg mice mouse neonatal normal observed occurs offspring organ pattern period Pharmacol physiological placenta points possible postnatal potential pregnancy prenatal Press produced protein pulmonary rabbit receptor reduced renal reported reproductive response risk secretion similar specific stage studies Table teratogenic Teratology tion tissue Toxicol Toxicology treatment weight women York