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Overweight - Continued

The estimates of overweight from the BRFSS are generally lower than those obtained in other surveys. During 1986, the median prevalence for overweight among the participating states was 20% for men and 19% for women. National data on the prevalence of overweight, based on actual measurement rather than on self-reported data from telephone interviews, are available from the 1976-1980 NHANES-II. When the NCHS reference was used, 24.2% of adult men and 27.1% of adult women were overweight (3). Self-reported data from face-to-face interviews in the 1985 Health Interview Survey indicated that 23.5% of adult men and 24.2% of adult women were overweight (7). The BRFSS and the NHANES-Il results may differ because the BRFSS does not include all states, or the discrepancy may indicate greater underreporting of body weight over the telephone than in face-to-face interviews (8).

The 1990 objective regarding the prevalence of overweight was recently revised to state: "By 1990, the prevalence of overweight (BMI of 27.8 or higher for men and 27.3 for women) among the U.S. adult population should be reduced, without impairment of nutritional status, to approximately 18% of men and 21% of women" (6). Because this objective is based on the prevalence of overweight derived from actual measurements, data from the upcoming NHANES-III will be required to assess progress. State health departments participating in the BRFSS can set similar objectives and can monitor their progress through telephone surveys. However, when interpreting their results, states must bear in mind the potential effects of telephone survey methodology on estimates of prevalence.

The second 1990 objective related to overweight states, "By 1990, 50% of the overweight population should have adopted weight loss regimens combining an appropriate balance of diet and physical activity" (6). This objective is supported by several studies that have found diet and exercise together to be more effective for weight loss than diet alone (9). Forty percent of overweight persons who reported trying to lose weight in the 1986 BRFSS were following this objective. References

1. Centers for Disease Control. Behavioral risk factor surveillance-selected states, 1986. MMWR 1987;36:252-4.

2. The Society of Actuaries. Build and blood pressure study 1959. Vol I and II. Chicago: The Society of Actuaries, 1959.

3. Najjar MF, Rowland M. Anthropometric reference data and prevalence of overweight-United States, 1976-80. Hyattsville, Maryland: US Department of Health and Human Services, Public Health Service, 1987. DHHS publication no. (PHS)87-1688. (Vital and health statistics; series 11, no. 238).

4. Forman MR, Trowbridge FL, Gentry EM, Marks JS, Hogelin GC. Overweight adults in the United States: the behavioral risk factor surveys. Am J Clin Nutr 1986;44:410-6.

5. Van Itallie TB. Health implications of overweight and obesity in the United States. Ann Intern Med 1985;103(suppl 6, pt 2):983-8.

6. Public Health Service. The 1990 health objectives for the nation: a midcourse review. Washington, DC: US Department of Health and Human Services, Public Health Service, 1986. 7. Stephenson MG, Levy AS, Sass NL, McGarvey WE. 1985 NHIS findings: nutrition knowledge and baseline data for the weight-loss objectives. Public Health Rep 1987;102:61-7.

8. Millar WJ. Distribution of body weight and height: comparison of estimates based on self-reported and observed measures. J Epidemiol Community Health 1986;40:319-23.

9. Björntorp P. Interrelation of physical activity and nutrition on obesity. In: White PL, Mondeika T, eds. Diet and exercise: synergism in health maintenance. Chicago: American Medical Association, 1982:91-8.

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The Morbidity and Mortality Weekly Report is prepared by the Centers for Disease Control, Atlanta, Georgia, and available on a paid subscription basis from the Superintendent of Documents, U.S. Government Printing Office, Washington, D.C. 20402, (202) 783-3238.

The data in this report are provisional, based on weekly reports to CDC by state health departments. The reporting week concludes at close of business on Friday; compiled data on a national basis are officially released to the public on the succeeding Friday. The editor welcomes accounts of interesting cases, outbreaks, environmental hazards, or other public health problems of current interest to health officials. Such reports and any other matters pertaining to editorial or other textual considerations should be addressed to: Editor, Morbidity and Mortality Weekly Report, Centers for Disease Control, Atlanta, Georgia 30333.

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Haemophilus b Conjugate Vaccine (Diphtheria Toxoid-Conjugate) has recently been licensed for use in children 18 months of age or older for the prevention of Haemophilus influenzae type b (Haemophilus b) disease. This vaccine consists of Haemophilus b capsular polysaccharide covalently linked to diphtheria toxoid (conjugate vaccine).

A previously developed vaccine consisting of the Haemophilus b capsular polysaccharide alone (polysaccharide vaccine) was shown to be effective in Finnish children over 24 months of age (1), the age group in which approximately 20% of all invasive Haemophilus b infections among U.S. children less than 5 years of age can be expected to occur (2). A similar, but not identical, polysaccharide vaccine was licensed for use in the United States in April 1985 on the basis of data demonstrating biochemical characteristics and immunogenicity comparable to the vaccine used in the original Finnish trial (3). In that Finnish trial, polysaccharide vaccine was not effective in children less than 18 months of age. Because of the small sample size, efficacy could not be demonstrated in children 18 to 23 months of age. Polysaccharide vaccine was immunogenic (as measured by antibody production) in children 18 to 23 months old, but less so than it was in older children (1).

Conjugate vaccine was developed with the ultimate goal of providing an effective vaccine for infants and younger children. Preliminary data from a new Finnish study suggest that conjugate vaccine was 87% effective in preventing Haemophilus b disease when administered in a three-dose regimen to infants 3 to 6 months of age (4). However, licensure of conjugate vaccine for use in infants in the United States cannot be considered until this and other efficacy trials are further evaluated. Since antibody production after vaccination with conjugate vaccine in children 18 months of age or older is substantially greater than that after vaccination with polysaccharide vaccine, conjugate vaccine has been licensed for use in these children.

Safety

When conjugate vaccine alone was given to over 1,000 adults and children, no serious adverse reactions were observed (5-12). When conjugate vaccine was given with diphtheria and tetanus toxoid and pertussis vaccine (DTP) and inactivated polio vaccine (IPV) to 30,000 infants, the rate and extent of serious adverse reactions did not

U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES/PUBLIC HEALTH SERVICE

US DEPOSITORY FEB 22 1988

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differ from those seen when DTP was administered alone (4). In one study of over 500 children 15 to 24 months of age, no significant difference in local or systemic side effects occurred between groups of children vaccinated with either polysaccharide vaccine or conjugate vaccine (7). Local reactions were noted for 10.3% of children receiving polysaccharide vaccine and 12.5% of children receiving conjugate vaccine, while moderate fever (temperature >39.0 °C [>102.2 °F ]) occurred in 1.4% of children vaccinated with polysaccharide vaccine and 0.7% of children vaccinated with conjugate vaccine.

Immunogenicity

In several studies using different regimens of vaccine administration, conjugate vaccine has shown greater immunogenicity than polysaccharide vaccine (5-9,11,12). Response to a single dose of either polysaccharide vaccine or conjugate vaccine in children 15 to 24 months of age was specifically addressed in a randomized, doubleblind study recently completed in the United States (7). More than 90% of children vaccinated with conjugate vaccine responded with antibody levels considered to be protective (0.15 μg/mL), whereas less than 50% of children vaccinated with polysaccharide vaccine had such a response. Over 60% of children vaccinated with conjugate vaccine, but less than 30% of those vaccinated with polysaccharide vaccine, produced levels of antibody considered to be indicative of long-term protection (1.0 μg/mL).* Children given conjugate vaccine at 15 to 24 months of age had significantly higher levels of antibody to Haemophilus b polysaccharide 1 year after vaccination than did children receiving polysaccharide vaccine (8). Conjugate vaccine recipients responded to a booster dose of either polysaccharide vaccine or conjugate vaccine with higher geometric mean antibody levels than did those initially vaccinated with polysaccharide vaccine (8).

In another study, children with sickle cell syndromes who received conjugate vaccine had higher postvaccination levels of antibody to Haemophilus b polysaccharide than did similar children given polysaccharide vaccine (13). The studies to date showing increased immunogenicity in children less than 18 months of age (5,6,9,11) suggest that conjugate vaccine may be functioning as a T-cell dependent antigen. This finding contrasts with the lack of immunogenicity in infants and the absence of immunologic memory characteristic of T-cell independent polysaccharide vaccines. Biological Activity

Several investigators have demonstrated that conjugate vaccine produces functional activity against Haemophilus b similar to that produced by polysaccharide vaccine. In one randomized, double-blind study, adults vaccinated with conjugate vaccine had serum bactericidal titers for Haemophilus b at least as high as those of adults receiving polysaccharide vaccine (12). In addition, sera from adults vaccinated with conjugate vaccine were protective in an infant rat model of Haemophilus b *It should be noted that three of four lots of polysaccharide vaccine used in this study had been heat-sized, a process which may reduce immunogenicity. However, children receiving non-heatsized polysaccharide vaccine also had postimmunization levels of antibodies to Haemophilus b polysaccharide that were lower than those observed in children vaccinated with conjugate vaccine. In another study in which vaccine recipients were tested at 1 month and again at 1 year after completion of the immunization series, 9- to 15-month-old children who had received two doses of conjugate vaccine had significantly higher titers of antibody to Haemophilus b polysaccharide than did similar children who had received two doses of non-heat-sized polysaccharide vaccine (5).

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disease, whereas similarly diluted sera from persons receiving polysaccharide vaccine showed no protective activity. In a separate study, sera from 9- to 14-month-old children given conjugate vaccine showed greater opsonic activity against Haemophilus b organisms than did sera from children vaccinated with polysaccharide vaccine (14). Both studies showed a correlation between functional activity and serum levels of antibody to Haemophilus b polysaccharide and suggest that antibody produced in response to conjugate vaccine is biologically equivalent to that produced in response to polysaccharide vaccine.

Immunization Practices Advisory Committee (ACIP) Recommendations

1. The ACIP recommends that all children receive conjugate vaccine at 18 months of age. The efficacy of conjugate vaccine in children 18 months of age or older has not been determined in field trials. However, studies comparing antibody production in children receiving conjugate vaccine with that in children receiving polysaccharide vaccine suggest that conjugate vaccine is likely to be more effective than polysaccharide vaccine. The ACIP therefore recommends use of conjugate vaccine in all children vaccinated against Haemophilus b disease.

2. While the duration of immunity after a single dose of conjugate vaccine is unknown at this time, it is expected to be at least 1.5 to 3 years. Until further information is available, revaccination is not recommended for children receiving conjugate vaccine at 18 months of age or older.

3. Vaccination of children more than 24 months of age who have not yet received Haemophilus b vaccine should be based on risk of disease. Children considered at high risk for Haemophilus b disease, including those attending day-care centers, those with anatomic or functional asplenia (i.e., sickle cell disease or splenectomy), and those with malignancies associated with immunosuppression, should receive the vaccine. Although risk of disease decreases with increasing age, physicians may wish to vaccinate previously healthy children between 2 and 5 years of age to prevent disease that can occur in this group.

4. Because many children who received polysaccharide vaccine between the ages of 18 and 23 months may have had a less than adequate response to the vaccine, they should be revaccinated with a single dose of conjugate vaccine. Revaccination should take place a minimum of 2 months after the initial dose of polysaccharide vaccine.

5. There is no need to routinely revaccinate children who received polysaccharide vaccine at 24 months of age or older.

6. Children who had invasive Haemophilus b disease when they were less than 24 months of age should still receive vaccine according to the above recommendations since most children less than 24 months of age fail to develop adequate immunity following natural infection (15).

7. Although increases in serum diphtheria anti-toxin levels can follow administration of conjugate vaccine, this vaccine should not be considered an immunizing agent against diphtheria. No changes in the schedule for administration of diphtheria toxoid, customarily given as DTP, should be made secondary to the use of conjugate vaccine.

8. Vaccination with either polysaccharide vaccine or conjugate vaccine probably does not inhibit asymptomatic carriage of Haemophilus b organisms. Although vaccinated children may be protected from invasive disease, they may pass the organism on to susceptible children. In addition, no vaccine is 100% effective.

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