LISTERINE Listerine is an efficient, non-toxic antiseptic of accurately determined and uniform antiseptic power, prepared in a form convenient for immediate use. Composed of volatile and non-volatile substances, Listerine is a balsamic antiseptic, refreshing in its application, lasting in its effect. Listerine is particularly useful in the treatment of abnormal conditions of the mucosa, and admirably suited for a wash, gargle or douche in catarrhal conditions of the nose and throat. In proper dilution, Listerine may be freely and continuously used without prejudicial effect, either by injection or spray, in all the natural cavities of the body. Administered internally, Listerine is promptly effective in arresting the excessive fermentation of the contents of the stomach. In the treatment of summer complaints of infants and children, Listerine is extensively prescribed in doses of 10 drops to a teaspoonful. In febrile conditions, nothing is comparable to Listerine as a mouth wash; two or three drachms to four ounces of water. "The Inhibitory Action of Listerine" (128 pages) may be had upon application to the manufacturers, LAMBERT PHARMACAL COMPANY, Locust and Twenty-first Streets ST. LOUIS, MISSOURI For "Building up" the Baby it is essential to supply nourishment that is not only easily digestible and assimilable, but nourishment that affords the various elements needed to insure growth of every tissue throughout the body-muscle, bone and special structure. This is why Nestlé's Food holds the place it does in the regard of so many thoughtful physicians. Cystogen CH.N A preferred product of hexamethylene tetramine remarkably free from irritating properties. PHYSIOLOGICAL ACTION Supplied as Cystogen-Crystalline Powder. Cystogen-Aperient (Granular Effer- Genito-urinary antiseptic and uric-acid solvent in doses of gr., V-X t. i. d.; increases the excretion of urine and of uric-acid. It causes the urine to become a dilute solution of formaldehyde with antiseptic properties. Specially valuable as a diuretic and urinary-antiseptic in cystitis, pyelitis, phosphaturia, before surgical operation on the urinary tract; during the course of infectious diseases to prevent nephritis; and as a solvent and eliminant in rheumatism and gout. When given in large doses, gr. X to XV, four times daily it is found in the saliva, secretions of the middle ear and nose, cerebrospinal fluid, bile; in short, in practically all secretions and excretions of the body, and hence its use as an antiseptic is indicated in Rhinitis, Otitis Media, Sinusitis, Bronchitis, Influenza and many other conditions which will at once occur to the clinician. PNEUMONIA still holds the record of causing more deaths than any other disease under conventional treatment. Vaccine Therapy is robbing pneumonia of that record! Early treatment is the most important factor in obtaining the best results, consequently stock vaccines should be employed and given at the earliest possible moment. Sherman's Pneumococcus Combined Vaccine (List No. 4) is absolutely reliable and most efficient. Write for literature. G. H. SHERMAN, M. D., Detroit, Mich. AMERICAN MEDICINE, A JOURNAL DEVOTED TO THE WELFARE AND PROG- "Owned, controlled and directed by physicians PUBLISHED BY THE AMERICAN MEDICAL PUBLISHING CO. PUBLICATION OFFICES: 189 COLLEGE STREET, BURLINGTON, VT. NEW YORK OFFICES: 84 WILLIAM STREET, NEW YORK CITY. H. Edwin LEWIS, M. D..................Managing Editor 84 William St., New York City. Subscription Price, One Dollar a Year in Advance. POSTAGE in the United States, Mexico, Hawall, ORIGINAL PAPERS.-Articles are accepted for publi- CORRESPONDENCE on all matters of clinical interest, COPYRIGHT.-Matter appearing in American Medi- ADVERTISEMENTS.-Advertising forms go_to_press CHANGE OF ADDRESS.-In ordering a change of ad- REMITTANCES.-Remittances should be made by MEDICAL PROGRESS. High Grade Pharmaceutical Products. Dr. W. A. Puckner, director of the chemical laboratory of the American Medical Association, investigated a number of the products furnished by twenty different pharmaceutical manufacturers and the degree of accuracy attained by each house was published in the Journal of the American Medical Association, September 13, 1913. The results are given in detail and make it possible to summarize or classify them in various ways. For example, the average strength of all the preparations made by each house may be calculated. An objection to this method, however, lies in the fact that the preparations above strength, of any one house, might exactly counterbalance the ones under strength and the house receive thereby a perfect mark. A more accurate method consists in calculating the average deflection from normal of the preparations of each house, and rank the houses in the contest in the order in which the average deflection is the least. A third method would consist merely in stating the highest and lowest deviation from standard found in the products of each house. BY WHATEVER THE METHOD THE RESULTS ARE SUMMARIZED, THE H. K. MULFORD COMPANY HEADS THE LIST FOR ACCURACY OF PRODUCTS. The preparations examined, namely, hypodermic tablets morphine sulphate, tablets potassium iodide, solution of potassium arsenite, fluid extract of hydrastis and fluid extract of digitalis, should be divided in summarizing results, into two classes. The first four mentioned are amenable to exact chemical assay and it is possible, therefore, to determine within a fraction of one per cent., the exact deviation from standard, or conversely, approach to perfection of these preparations. Their standards are definitely fixed, either by the Pharmacopeia or by the manufacturers' claim-100 per cent. of the claimed strength being the target at which each manufacturer aims. The other preparation, however, namely, fluid extract digitalis, is one for which no definite standard of strength has been fixed. The preparation is official but no assay processes have been provided by the Pharmacopeia, so that a preparation made in strict accordance with the U. S. P. directions may vary enormously in activity. A limited number only of the houses chosen for this contest make any attempt to standardize digitalis preparations. A few, however, have adopted physiologic methods of assay in an attempt to put on the market preparations of uniform strength. Even in the absence of a fixed and official standard of strength, it is obvious that a fluid extract of digitalis should have represented in each cubic centimeter, one gram of a good quality of drug. Dr. R. A. Hatcher, of Cornell University Medical School, who examined the digitalis samples for Dr. Puckner, and made a special study of this drug for a number of years, is the inventor of the process by which these samples were examined, and is fully competent, therefore, to express an opinion as to whether a preparation does represent a digitalis drug of good quality. Dr. Hatcher's results with the nineteen fluid extracts examined in this contest forced him to the conclusion that THE FLUID EXTRACT OF THE H. K. MULFORD COMPANY FULLY REPRESENTED A DIGITALIS DRUG OF GOOD QUALITY AND THAT THE NEXT IN VALUE ONLY POSSESSED 65.8 PER CENT. OF THE STRENGTH OF THE MULFORD PREPARATION. The H. K. Mulford Company Fluid Extract Digitalis was therefore taken as the standard, or 100 per cent. The other 18 preparations ranged from 65.8 per cent. down to a minimum of 29.25 per cent. It cannot be claimed by those whose fluid extract digitalis was found to be weak in comparison with the H. K. Mulford Company sample that the latter is too strong, because Dr. Hatcher states that the Mulford preparation represents a good quality of drug. To the credit of all of the firms, Dr. Puckner states that there was found no evidence of willful sophistication or adulteration in any product examined. He believes that none of the houses deliberately adulterate or sophisticate their standard drugs, but that the products of many of them are made by those "who are less competent and less skilled" than the others. It is the more complimentary to the H. K. Mulford Company, therefore, that it should attain the first place, with those who are doing their best to furnish standard articles. It is an emphatic endorsement of the competence and skill shown by the H. K. Mulford Company, and products of their manufacture. Throat Affections. In all acute or chronic inflammations of the throat, pharyngitis, tonsillitis and laryngitis especially, Gray's Glycerine Tonic Comp. will be found of exceptional value. Used in appropriate dosage it allays congestion of the mucous membrane and underlying tissues, thus relieving pain and soreness, and by imparting tone to the local structures helps to restore normal conditions. "Gray's," moreover, is particularly useful as a prophylactic measure in those patients who are peculiarly subject to frequent colds. In such cases, its use from time to time tends to increase the resistance of the local mucous membrane and enables it to successfully combat germ attack. Public speakers and singers are also greatly benefited by "Gray's" and if administered for several days before putting the throat or voice to unusual strain, it can be relied upon to increase the strength and vitality of the local structures. |