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AMERICAN MEDICINE.

A JOURNAL DEVOTED TO THE WELFARE AND PROG-

BESS OF THE AMERICAN PHYSICIAN.

"Owned, controlled and directed by physicians

in active practice.”

PUBLISHED BY
THE AMERICAN MEDICAL PUBLISHING CO.

PUBLICATION OFFICES:
189 COLLEGE STREET, BURLINGTON, VT.

POSTAGE in the United States, Mexico, Hawali,
Guam, Porto Rico and the Philippines, free ; foreign
postage, 50 cents. Subscriptions may begin at any
time. Volumes end with the last issue of December.

ORIGINAL PAPERS.- Articles are accepted for publi-
cation with the understanding that they are contrib-
uted solely to this journal. Brief clinical papers
(2,000 words or less) are especially valued.

CORRESPONDENCE on all matters of clinical Interest,
particularly with reference to therapeutics, will be
welcomed. Unobjectionable questions concerning for.
mulas, treatment, etc., will receive attention in the
department of Treatment.

COPYRIGHT.—Matter appearing in American Media
cine is covered by copyright, but usually no objection
will be made to the reproduction of anything appear.
ing in its columns if the author's consent is obtained
and proper credit is given.

ADVERTISEMENTS.-Advertising forms go to press
10 days in advance of the date of issue. Therefore,
in sending in copy, time should be allowed for setting
up advertisements and for the sending and return of
proofs. Advertising rates will be furnished on appll-
cation.

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dress it is important that both the old and new ad-
dress be given.

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ing Company.

NEW YORK OFFICES:
84 WILLIAM STREET, NEW YORK CITY.

H. EDWIN LEWIS, M. D....... Managing Editor
WM. T. HANSON..

..Business Manager
84 William St., New York City.

Subscription Price, One Dollar a Year in Advance.

Single Copies, 15 Cents.

61

INDEX OF ADVERTISERS
PAGE
Farm Colony and Sanitarium 61 Od Chemical Co....

24
Abbott Alkaloidal Co.......... 51 Fallows' Co. of New York.. 9 O'Sullivan Rubber Co.... 63
Akron Tire Co..
42 Pougora, E. & Co. 4th page cover

Packer Mfg. Co......

29
Aloe Co., A. S..... ........30, 33 French Lick Springs Co...... 38
Anasarcin Chemical Co....... 56 Fries Bros........

Paige-Detroit Motor Car Co. 43
26

Parke, Davis & Co. 2nd page cover
Anheuser-Busch .....

47
Angier Chemical Co....... 7 Glen Springs Sanitarium....... 59 Peacock Chemical Co.........

36 Goodwin Corset Co........... 39 Philo Burt Mig. Co.........
Armour & Co.....

7
Pomeroy Co.....

31
Atwood Grape Fruit Co.,
Hance Brothers & White 54

Pond's Extract Co.,
3rd page cover

.26,57
Hendee M'f'g. Co ......... 46

Postum Cereal Co., Ltd..... 23
Australian Eucalyptus Chemi- Henry Pharmacal Co.......... 13 Purdue Frederick Co..........1, 50
cal Co.......
10 Hoffmann-La Roche Chemical

Pure Gluten Food Co..... 59
Automobile Tire Co., Inc... 44

Works.

6

39 Radium Chem. Co.
Bannerman & Co., Wm........
Hydrox Chemical Co..........

12
12

Regent Drug Co......

27
Bauer Chemical Co...... 32 Johns-Manville Co., H. W. 59 Reinschild Chemical Co. 53,59,61
Barrett Mfg. Co.....
35 Jordan & Bertrand

59
Rio Chemical Co.....

2,38
Bolton Chemical Corp. 13
Bovinine Co..

River Crest Sanitarium...
9 Knoll & Co..........

24
Breitenbach, M.J., Co....... 15 Kress & Owen Co.

19 Saxlehner, Andreas........ 28
Bristol-Myers Co.
Lambert Pharmacal Co.......

3
Schering & Glatz

16
Brown Scientific Tube Co... 42

Schieffelin & Co.,.... .17,57
Leach & Co., A. B.....

61
Burnham Soluble lodipe Co. 53
Leather Tire Goods Co......

Sharp & Dohme

27
44

Sherman, G. H., M. D........ 17
Campho-Phenique Co.

Lehn & Fink....

1
Carlsbad (Bohemia).....
61 Lowell, G.

61

3rd page cover

Smith, Martin H., Co......... 2, 59
Chesebrough M'f'g. Co...... 37

Marks, A. A.

5 Storm, M. D., Katherine L.
Chicago Eye, Ear, Nose &

Marvel Co.........
Throat College

34 Strong, F. H., Co.

10
61

Medico-chirurgical College
Chinosol Co......

Sultan Drug Co.

2
11

of Philadelphia
Clysmic Spring Co..

57 Trommer Co.......

64

45
Cocroft, Susanna
37

Valentine's Meat Juice Co.
Merrell, Wm. S., Chemical
College of Physicians & Sur.
Co.

4th page oover

21
geons of Boston.....
61

Van Horn & Sawtell..lst cover, 53
Coward, James S..............

Morgan, T. C. & Co.

53
31
Morgan & Marshall Rubber

Vapo-Cresolene Co.......... 28
Cystogen Chemical Co. 17

& Tire Co..

45

Wallau, Geo.J., loc. ..48, 49, 54
Denver Chemical Mfg. Co... 14 Mulford Co., H. K.....

25
Weissfeld Bros..

61
Dios Chemical Co.......
11

Welch Grape Juice Co.........
Nestle's Food Co.......
16 Wolff Co., Wm. F.

62
Emery M'l'g. Co........ 44 N. Y, Pharmaceutical Co... 5 Wulfing & Co., A.

40

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29 Metz Co..

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20

MEDICAL PROGRESS.

High Grade Pharmaceutical Products.

Dr. W. A. Puckner, director of the chemical laboratory of the American Medical Association, investigated a number of the products furnished by twenty different pharmaceutical manufacturers and the degree of accuracy attained by each house was published in the Journal of the American Medical Association, September 13, 1913.

The results are given in detail and make it possible to summarize or classify them in various ways. For example, the average strength of all the preparations made by each house may be calculated. An objection to this method, however, lies in the fact that the preparations above strength, of any one house, might exactly counterbalance the ones under strength and the house receive thereby a perfect mark.

A more accurate method consists in calculating the average deflection from normal of the preparations of each house, and rank the houses in the contest in the order in which the average deflection is the least.

A third method would consist merely in stating the highest and lowest deviation from standard found in the products of each house.

BY WHATEVER THE METHOD THE RESULTS ARE SUMMARIZED, THE H. K. MULFORD COMPANY HEADS THE LIST FOR ACCURACY OF PRODUCTS,

The preparations examined, namely, hypodermic tablets morphine sulphate, tablets potassium iodide, solution of potassium arsenite, fluid extract of hydrastis and fluid extract of digitalis, should be divided in summarizing results, into two classes. The first four mentioned are amenable to exact chemical assay and it is possible, therefore, to determine within a fraction of one per cent., the exact deviation from standard, or conversely, approach to perfection of these preparations. Their standards are definitely fixed, either by the Pharmacopeia or by the manufacturers' claim-100 per cent. of the claimed strength being the target at which each manufacturer aims.

The other preparation, however, namely, fluid extract digitalis, is one for which no definite standard of strength has been fixed. The preparation is official but no assay processes have been provided by the Pharmacopeia, so that a preparation made in strict accordance with the U. S. P. directions may vary enormously in activity. A limited number only of the houses chosen for this contest make any attempt to standardize digitalis preparations. A few, however, have adopted physiologic methods of assay in an attempt to put on the market preparations of uniform strength.

Even in the absence of a fixed and official standard of strength, it is obvious that a fluid extract of digitalis should have represented in

each cubic centimeter, one gram of a good quality of drug.

Dr. R. A. Hatcher, of Cornell University Medical School, who examined the digitalis samples for Dr. Puckner, and made a special study of this drug for a number of years, is the inventor of the process by which these samples were examined, and is fully competent, therefore, to express an opinion as to whether a preparation does represent a digitalis drug of good quality.

Dr. Hatcher's results with the nineteen fluid extracts examined in this contest forced him to the conclusion that THE FLUID EXTRACT OF THE H. K. MULFORD COMPANY FULLY REPRESENTED A DIGITALIS DRUG OF GOOD QUALITY AND THAT THE NEXT IN VALUE ONLY POSSESSED 65.8 PER CENT. OF THE STRENGTH OF THE MULFORD PREPARATION.

The H. K. Mulford Company Fluid Extract Digitalis was therefore taken as the standard, or 100 per cent. The other 18 preparations ranged from 65.8 per cent, down to a minimum of 29.25 per cent.

It cannot be claimed by those whose fluid extract digitalis was found to be weak in comparison with the H. K. Mulford Company sample that the latter is too strong, because Dr. Hatcher states that the Mulford preparation represents a good quality of drug.

To the credit of all of the firms, Dr. Puckner states that there was found no evidence of willful sophistication or adulteration in any product examined. He believes that none of the houses deliberately adulterate or sophisticate their standard drugs, but that the products of many of them are made by those "who are less competent and less skilled” than the others. It is the more complimentary to the H. K. Mulford Company, therefore, that it should attain the first place, with those who are doing their best to furnish standard articles. It is an emphatic endorsement of the competence and skill shown by the H. K. Mulford Company, and products of their manufacture.

Throat Affections.

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In all acute or chronic inflammations of the throat, pharyngitis, tonsillitis and laryngitis especially, Gray's Glycerine Tonic Comp. will be found of exceptional value. Used in appropriate dosage it allays congestion of the mucous membrane and underlying tissues, thus relieving pain and soreness, and by imparting tone to the local structures helps to restore normal conditions. “Gray's," moreover, is particularly useful as a prophylactic measure in those patients who are peculiarly subject to frequent colds. In such cases, its use from time to time tends to increase the resistance of the local mucous membrane and enables it to successfully combat germ attack. Public speakers and singers are also greatly benefited by “Gray's" and if administered for several days before putting the throat or voice to unusual strain, it can be relied upon to increase the strength and vitality of the local structures.

NEGLECT OF MENSTRUAL DISORDERS NECESSITATES MANY A SURGICAL OPERATION

The functional derangements of the female generative organs seldom require operative treatment if taken in time. They are amenable to medical treatment such as is afforded by

GENITONE

This utero-tonic cordial owes its exceptional therapeutic power to the rational formula and the definite special action of each of the incorporated drugs used in the fresh state-a vitally important feature.

Genitone is composed of Viburnum Prunifolium, Hydrastis, Pulsatilla, Passiflora, Senecio.

Clinical experience is expressed in these quotations.

"The various abnormal conditions which often accompany the establishment of menstruation are surely met by Genitone, especially when there are pains, either spasmodic or continuous, nervousness, headache, şcant Alow, intermittent or continuous with or without fever."

"I have practically discarded all other viburnum preparations and use Genitono exclusively in my practice, with better results than I have been able to obtain with any other remedy."

"As a preventative of miscarriage or apparent premature labor, it will be of excellent service, provided the membranes are intact."

"As a uterine tonic and restorative following miscarriage or childbirth, this remedy is unexcelled."

"In my own practice I bave always used Genitone and find it perfectly meets all requirements as a regulator of functions."

“I have used Genitone in several cases of dysmenorrhea with perfect

success.

“For the derangement incident to menopause, I find Genitone always to be a successful and satisfactory remedy."

As the full value of Genitone can bardly be demonstrated by a small quantity, we will send prepaid to any physician wbo bas never prescribed it one only full size bottle on receipt of 50 cents to cover tbe delivery and packing expense. The price of plat bottles is $1.00. Gepitone is carried in stock by leading drugglsts everywhere

THE WM.S.MERRELL CHEMICAL OMPANY

CINCINNATI

use

new

High Grade Serums and Bacterins. The physician desirous of achieving the utmost possible success finds himself each day using a greater variety of serums and bacterins.

Clinical experience with modern standard biologic products must convince even the most ardent adherent of drug therapy or surgical procedure of their extraordinary efficacy in that extensive and extremely troublesome class of ailments due to the presence of microorganisms.

The beneficial results obtained from the intelligent of these comparatively remedial agents are so pronounced, so rapidly produced often, as to prove startling to the therapeutist accustomed to the slower action of drugs. It is evident that in the therapeutics of the near future biologic medications and drug therapy will go hand in hand.

The Abbott Laboratories recognizing in properly prepared serums and bacterins the best available means to obtain a desired therapeutic result, are prepared to supply every tried and desirable biologic product in syringe packages and ampules. The "Slee special” syringe is acknowledged to be the most practical and convenient container available and is used exclusively by the Board of Health of New York City.

The prices are as low as is consistent with perfection of product, and the demand for Abbott Biologics is steadily increasing. A 32 page booklet, "Biologic Products and How to Use Them," and a copy of “Prices Current,” a cloth bound 400 page volume filled with practical success-making information can be ob tained on request from The Abbott Laboratories, Ravenswood, Chicago. Better secure your copies now.

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The Element of Uncertainty.

The Doctor and His Automobile. No longer is an automobile a luxury for the physician. Now that cars are available that are thoroughly reliable in every respect, that can be depended upon to go the instant they are called upon, and keep going day in and day out, "up hill and down dale," as long as fuel and oil and provided, they are an absolute necessity for busy doctors. It is not necessary to refer to the many advantages that accrue to busy practitioners from owning good automobiles. The greater convenience, the larger amount of work that can be done, and the saving in expense, have all been demonstrated time and time again. But there is one benefit that comes from owning and driving a high class car that we have never seen mentioned. This is the soothing, quieting, restful effect which comes from speeding along in a car that has ample power, runs like a watch, is as comfortable as an easy chair, and finally that affords perfect protection against any and all weather. There is such a delightful sense of ease and comfort to be de rived from driving such a car that one feels at peace with the whole world. The little cares and worries fade away and annoyances that seemed overpowering are forgotten in the joy of seeing the road slip by and hearing the soft purr of the motor. Restful indeed is the effect produced and one quickly gathers new poise, and the power to meet and overcome all unpleasant or difficult problems.

Of all the cars that medical men have found particularly adapted to their exacting requirements, none has proven so nearly perfect as the beautiful Paige Coupe. If ever an automobile deserved to be called an ideal doctor's car it is this one. Beautiful in appearance, with the class and dignity a doctor's car should have, it is unexcelled in the essential details of convenience and reliability. Splendidly equipped, nothing that could add to its serviceability has been omitted. Lack of space precludes any extended description of this beautiful car. The reader is urged to turn to the advertisement on page 43 and then send for a booklet which will give full information concerning every detail and specification. No doctor who has the slightest idea of getting a new car should fail to investigate the Paige Coupe, for there is no automobile available to-day that offers so much at the price asked, or that comes so closely to being the ideal car for the doctor.

In the treatment of disease the element of uncertainty with special reference to individual idiosyncrasy, must always be considered, but the element of uncertainty as to the therapeutic action of a remedy can be eliminated providing ordinary care is exercised in selecting drugs or remedies which are not inert and have proven their efficiency.

For over 45 years, Hayden's Viburnum Compound has maintained its reputation as therapeutically efficient in the treatment of Dysmenorrhea, Menorrhagia, Post-partum Pains, Puerperal Convulsions and in pain resulting from spasmodic contraction.

It is a well known anti-spasmodic and as it contains no narcotics nor habit forming drugs, no disagreeable after effects is the result of its administration.

Given in teaspoonful doses, administered in boiling water, it will not disappoint you, thus eliminating the element of uncertainty, and as it is not a secret remedy, but a carefully compounded and ethical pharmaceutical, it will render most satisfactory results in those conditions wherein especially indicated.

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