 | Joseph Glenmullen - 2001 - 388 pages
...tranquilizers, especially permanent tics.45 Twenty years after Thorazine had been introduced, Crane lamented, "Many physicians are still unaware of this problem or seem to be completely unconcerned about it." Crane estimated that tics occurred in "at least 5% of patients exposed to drugs for several years.... | |
 | Edward Shorter - 2005 - 352 pages
...(p. 41). In a 1973 article in Science on "late, unanticipated effects of neuroleptics," Crane said, "Many physicians are still unaware of this problem...are administered routinely for long periods of time" (p. 127). By this time, Crane was research director of the Spring Grove State Hospital in Baltimore.... | |
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... 1967, there was a considerable body of evidence to indicate that tardive dyskinesia was caused by neuroleptics, that it occurred in at least 5 percent of patients exposed to drugs for several years, and that it could be observed in young adults as... 