Dementia and Normal AgingFelicia A. Huppert, Carol Brayne, Daniel W. O'Connor Cambridge University Press, 1994 M06 30 - 573 pages Age has been identified as the strongest risk factor for Alzheimer's disease, and is also strongly associated with vascular dementia. With this relationship in mind, this book looks upon the challenge of dementia as establishing its true relationship with normal aging. The traditional disease model of dementia may have obscured important clues about many underlying causes and features of dementia. In this book, experts and pioneers in the fields of aging and dementia make an important contribution to the understanding of dementia by reappraising the latest research in the light of the continuum model. Evidence for and against numerous models of dementia are discussed with particular relevance to the relationship between Alzheimer's and normal aging. Ranging from molecular genetics and fundamental neurobiology to issues of diagnosis and the provision of services, this is a challenging work in its breadth and level of argument, which has far reaching implications for the study of dementia, and indeed of the mind itself. As a review of current thinking and research it will serve as an essential text for clinicians and scientific investigators. |
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abnormal age-related aging and dementia Alzheimer Alzheimer type Alzheimer's disease amyloid amyloid precursor protein Archives of Neurology assessment associated atrophy behaviour brain Brayne British Journal Cambridge CAMDEX cell cerebral cerebral cortex changes cholinergic chromosome clinical cognitive function cognitive impairment computed tomography continuum controls correlation cortex cortical criteria decline deficits dementia and normal diagnosis Epidemiology examination frontal gene genetic genetic linkage Geriatric Health hippo hippocampus Huppert increase individuals Journal of Psychiatry lesions Lewy body Lewy body dementia linkage lod score loss measures memory impairment mental disorders mild dementia mutation neurofibrillary tangles Neurology neurons Neuropathology normal aging normal elderly O'Connor old age pathology patients performance Perry persons plaques and tangles population prevalence problems rates receptor redn Retro risk factors Roth sample score semantic senescence senile dementia specific studies syndrome syntactic tau protein tests tomography undem vascular dementia visuospatial